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7

Yes it is possible to culture plasmodia but they don't grow in a simple constituted medium. Usually RPMI supplemented with serum and erythrocytes is used for growing plasmodia ex-vivo. This article discusses the issues related to plasmodial culture in detail. The authors say that sometimes a certain growth stage (in particular gametocyte) is lost on ...


5

I don't know anything about this topic, but I did find this recent paper: Kamaljit Singh,Hardeep Kaur, Kelly Chibale, Jan Balzarini, Susan Little, Prasad V. Bharatam (2012) 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies. European Journal of ...


5

This may be the paper you are looking for: Ongaroraa DSB, Gutb J, Rosenthalb PJ, Masimirembwac CM, Chibale K. 2012. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation. Bioorganic & Medicinal Chemistry Letters, 22(15): 5046–5050, doi:10.1016/j.bmcl.2012.06.010.


5

The uninucleate sporozoites are injected by the mosquito into a human host. They mature in the liver parenchymal cells in schizonts. Each schizont releases into the blood flow 2,000 to 40,000 uninucleate merozoites. Each of them can infect a red blood cell. Here, a merozoite can release other 10 to 36 merozoites [1]. The numer of injected sporozites depends ...


2

I wasn't sure when I first read this, but this is actually a very interesting question. Right now there seem to be two completely divorced lines of inquiry that researchers are pursuing with respect to the antimalarial drugs. One group of researchers is working on working out the mechanism by which say, chloroquine and its ilk bind to and interfere with ...


2

The experience of a former adviser of mine was that some people who are not taking anti-malarial medication can still resist infection with Plasmodium falciparum, one of the parasites responsible for malaria. The parasite's life cycle includes stages inside the Anopheles sp. mosquito, and they are transmitted to human host via the female mosquito's saliva ...



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