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In meiosis, homologous recombination occurs. Two Spo11 proteins utilize tyrosines to induce a double-stranded break in the DNA. Spo11 has no specific cleavage site. However, cleavage by Spo11 lead to the discovery of Spo11-Oligonucleotide (Spo11 w/ attached oligonucleotide post-cleavage) complexes which could be mapped to 'hotspots' which the linked study ...


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In humans and mice anyway ,a lot of it boils down to the recognition of a specific sequence that marks recombination hotspots by PRDM9. http://www.sciencemag.org/content/327/5967/836 Edit - I'm expanding in response to the comment below... Meiotic recombination occurs at vastly greater frequencies in some locations in the genome than others and these are ...


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The question is very broad and complicated, since the situation may differ in prokaryotes and eukaryotes. Nevertheless, I'm citing a good paper that is closely related to your question: Studies in yeast show that initiation of recombination, which occurs by the formation of DNA double-strand breaks, determines the distribution of gene conversion and ...



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