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Substituting a single amino acid and checking the effect this has on a protein is a method to determine what this specific amino acid does in the protein. For example, substituting an amino acid that is part of the catalytic core would almost always make the protein non-functional. Alanine scanning is a technique that methodically replaces amino acids in a ...


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The amount of recombination events does not have anything to do with homologous recombination repair and meiotic homologous recombination, protein-wise. Homologous recombination repair is a "very safe" repair system, especially compared to the alternative option, Non Homologous End Joining, which is really prone to indels. On the other hand, meiotic ...


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Great question and in part, you are correct. However, you must also remember that this greatly depends on what genes have undergone mutation. In the case of cancer, it's usually either a gene that regulates cell proliferation rates, induces programmed cell death or helps to repair damaged DNA. When one (or all) of these genes is mutated, the cell ...


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This is a good question and it gets to the most basic foundations of immunology. Your immune system is made to be flexible - able to adapt to almost any challenge. However, with so much flexibility comes the potential to generate immune cells that react against the 'self'. So, at the other extreme, the immune system needs to be limited. In order to meet ...



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