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There are lots and lots of specific single mutations that cause problems with apoptosis. Some of the most common are in P53, PTEN, MYC, APC, and KRAS. If you want a specific amino acid change, KRAS G12D is particularly potent. It works by disabling a regulatory domain and causing KRAS to be constitutively active. These aren't "reversible" in a strict sense ...


@Remi.b I think we can do better than 1962. Let's fast-forward here to 2014, in the post-genomic era. I think this paper provides some data relevant to your query: Possible mechanisms for Chromothripsis .

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