Tag Info

New answers tagged

4

Cancer is commonly defined as uninhibited cellular replication caused by mutations to the genome. Genes where cancer-causing mutations have been identified are known as oncogenes; the COSMIC (Catalogue Of Somatic Mutations In Cancer) database lists all of the known oncogenes (547 to date - 23rd Jan 2015 - 1% of all human genes!) [1]. The effect of a ...


2

Found a tool: MUMmer is a system for rapidly aligning entire genomes. The current version (release 3.0) can find all 20 base pair maximal exact matches between two bacterial genomes of ~5 million base pairs each in 20 seconds, using 90 MB of memory, on a typical 1.8 GHz Linux desktop computer. If you know a better programmatic approach, let me know, ...


0

The real mutation rate of any organism depends by too many factors both external, like the environment, and internal, like the error rate of the DNA polymerases and DNA-repair enzymes and even from different region in the same genome (the mutation rate of non-coding DNA tend to be higher than the one of actively used DNA). In general however it is possible ...


1

A good post about "mixing", which means that a population generally harbors multitude of different versions of a gene, called alleles. So one organism, like a human, has a unique combination of which two alleles out of thousands possible represent each gene in its body. Besides this, major changes are often made not so much by mutations as by changes in the ...


9

A single substitution can often be silent, or at least not impact the structure and function of the resulting protein in a significant way. But what you describe is a frameshift, and that is one of the most destructive mutations. It will completely change the sequence of the protein after this mutation and disrupt the function of those parts of the protein. ...



Top 50 recent answers are included