New answers tagged mutations
There are lots and lots of specific single mutations that cause problems with apoptosis. Some of the most common are in P53, PTEN, MYC, APC, and KRAS. If you want a specific amino acid change, KRAS G12D is particularly potent. It works by disabling a regulatory domain and causing KRAS to be constitutively active. These aren't "reversible" in a strict sense ...
@Remi.b I think we can do better than 1962. Let's fast-forward here to 2014, in the post-genomic era. I think this paper provides some data relevant to your query: Possible mechanisms for Chromothripsis .
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