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Short answer As far as I am aware, neurotoxic effects of chronic excitatory stimulation are not prevented by receptor trafficking. Background I think the question assumes that 1) neural damage related to continuous activation (excitotoxicity) is preventable by 2) the dynamic regulation of receptor numbers on the neuronal membrane. As far as I can see, ...


In principle, many neurotransmitter receptors work as ion channels and the actual mechanism of signalling involves allowing the influx/efflux of calcium, potassium, magnesium, etc. A good example of this is the acetylcholine receptor. Presumably, if the cell retained the same number of receptors even in the presence of abundant ligands, the cell would flood ...

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