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Short answer(s) Widening of the action potential increases neurotransmitter release; Generally, an action potential results in the release of about one vesicle of neurotranmitters; An action potential does not have to lead to neurotransmitter release - the chance being anywhere between 9 - 100%, depending on the synapse under investigation. ...


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Neurons encode the "largness" of the stimulus in firing frequency. Neurotransmitters are stored in vesicules near the end of the axon. It has been shown that neurotransmitter release follows Poisson-distribution and that usually a single "packet" (quantum) is released - this is known as quantal release. Although the actual number of molecules in a single ...


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Cocaine is cardiotoxic. After chronic exposure to high doses I would assume that primary damage would attack the cardiovascular system before levels of dopamine would be able to cause damage. Cocaine intoxication deaths have mostly been caused by this cardiotoxicity. Primarily, myocardial infarction, arrhythmia, heart failure, and sudden cardiac death are a ...



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