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6

A reasonable question, but it contains a fallacy. This is because what are referred to as the forward and reverse reactions being catalysed by different enzymes are generally not, in fact, the same overall reaction. Consider the relationship between DNA and its constituents (or RNA or Protein or fatty acid). You may be thinking of this as: DNA ⇌ DNA ...


9

The mechanism of aconitase classifies it as a lyase, even if (under most physiological conditions), the relative concentrations of substrates results in it catalysing the conversion of citrate to isocitrate. In short, it is not an isomerase because the substrate is released after each step. As the mechanism of aconitase shows, it catalyses the conversion ...



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