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The question is little bit unclear: is in vitro or in vivo introduction in question? In vivo: As the nematode feeds on the plant during its parasitic phase, it consequently assures the introduction of dsRNA and/or siRNA molecules into the nematode’s digestive system. in vitro introduction etc -> The status of RNAi-based transgenic research in ...


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Transcytosis is a process by which large macromolecules are transported across a cell, such as those in the intestinal epithelium. It is used by many toxins and even whole organisms to enter the body. Botulinum toxin also apparently uses this mechanism. I'm not sure how detailed of an answer you want, but the linked to-review is pretty in-depth.


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I've had a difficult time getting anything definitive to support my answer to your specific question of safety, however, I thought I'd go out on a limb and give you my understanding. A recent review of what is known about this can be found at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809506/ I think you are on the right track with your 'dose-dependence' ...



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