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I found my answer here ISSUES RELATED TO PARTICULAR CLASSES OF VECTORS FOR GENE THERAPY http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/CellularandGeneTherapy/ucm072987.htm#vi


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The answer lies in the question. Liver cirrhosis constrains hepatocytes into small fibrous spaces limiting regeneration, hence the nodular pattern. However,fibrous degeneration occurs in specific patterns. It can be located mostly around portal regions (centrolobular pattern) or diffusely through the whole lobule. So basically, it is all good that ...


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Dangerous Contacts were defined as premises where animals have been in direct contact with infected animals or have, in any way, become exposed to infection Contigous Premises are defined as a category of dangerous contacts where animals may have been exposed to infection on neighbouring infected premises Tildesley, Michael J., et al. "The role of ...



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