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Spironolactone works through a mechanism different than the adrenergics. You said of the ABC approach, "This includes also diuretics." That's why Spironolactone was included. Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange ...


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I think that the claim "different drugs properties come from different part of the world" is an illusion due to statistical mis-considerations. More accurately, there are 3 statistical issues here. Your sample size is too small to draw any conclusion. You only have 3 observations in one group and 2 in the other group. Your observations are not ...


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There are, indeed, several such mAb based treatments. From the Mayo Clinic: The monoclonal antibody drug rituximab (Rituxan) attaches to a specific protein (CD20) found only on B cells, one type of white blood cell. Certain types of lymphomas arise from these same B cells. When rituximab attaches to this protein on the B cells, it makes the cells more ...


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According to Drugbank and the articles cited below, Levomepromazine is an antagonist of several different receptors: These include dopaminergic 2, dopaminergic 4, alpha-1 adrenoceptor, 5HT-2, histamine type 1 and muscarinic-cholinergic receptors. References: Evidence for the use of Levomepromazine for symptom control in the palliative care setting: a ...


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The following is one of the many elegant statements in General Anesthetic Actions on GABAA Receptors: It is the fervent view of the authors that general anesthesia is no different from any other pharmacological process: exogenously administered drugs interact with key sites on cellular proteins in the body which results directly in the alteration in the ...


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The differences in the action/indication is because of differential affinity of the two molecules to different adrenergic receptors. The wikipedia page on Ardenergic receptor has a table which summarizes this. Wikipedia doesn't cite references for it. You may have a look at some of the following old articles. α- and β-Adrenergic Receptor Subtypes In ...


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Clonidine is an agonist on the α2 receptor... but then again norepinephrine is also an agonist on the α2 receptor. Then the physiologic ligand of the a2 receptor, norepinephrine is autocrine (meaning it is released from a cell then binds on a receptor on the same cell) causing negative feed back and it inhibits further release of norepinephrine from the ...


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Pyridostigmine is an analog of neostigmine, so has the same basic mechanism of action. Please forgive me for repeating information you may already know. There are two main families of acetylcholine receptors: muscarinic and nicotinic. Acetylcholine receptors at the neuromuscular junction (NMJ) are exclusively nicotinic (N1 or NM), so that's the only ...


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How can you differentiate between effects and side-effects of this adrenoblocker in PubChem? I think PubChem will list all sites (receptors) at which a drug reacts, rather than the preferred sites, which I think is appropriate. The pharmacological properties are listed in Section 8: Pharmacology and Biochemistry: Pharmacology Bisoprolol is a ...


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Lithium changes the effect of at least three substances that play a role in diuresis: aldosterone: lithium partially inhibits its ability to increase the expression of ENaC receptors on apical membrane thus increasing sodium losses [1]. arginine vasopressin (AVP): because lithium can induce hyperparathyroidism, parathyroid hormone can act as partial ...


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An agonist works with the receptor: a substance that initiates a physiological response when combined with a receptor; in the case of salbutamol (or albutarol in the US) they activate the beta-2 receptor on the muscles surrounding the airways. They are also known as sympathomimetics, as they imitate β2 adrenergics. A blocker (or antagonist) is one that that ...


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Anongoodnurse provide an excellent comment in other discussion about how to search PubChem. Ephedrine is not alpha2 mimetic. Pseudoephedrine is alpha2 mimetic, source:


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The answer can be found in PubChem, which is linked in the comment by anongoodnurse. I would not say that Norepinephrine is beta2 adrenomimetic because norepinephrine has many roles such as neurotransmitter. I would just say that Norepinephrine is alpha, beta adrenoagonist. More pieces of information about it from PubChem:



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