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Short answer The causes of death after heroin, cocain or cannabis overdose are mainly due to cardiac and respiratory arrest, and not to neurotoxic effects. Background The cause of death after a lethal overdose of your mentioned drugs, and heroin for reference, are the following : Cocaine (lethal dose: 30 mg - 5 g via mucus membrane (EMCDDA)): ...


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The problem is the glucosepane bond is very strong, hence the molecules which would break this bond need be necessarily toxic and damaging to other molecules in the body. Glucosepane breakers already exist, but they are too toxic, and perhaps all will necessarily be that way. All hope is not lost however. Other very effective medical drugs (like clot ...


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As far as I can see this paper is being a little misleading, by saying "VPA mimics Nogo-66 receptor deletion". The action of VPA doesn't seem to be related to this receptor. It seems that blocking this receptor and applying VPA both increase plasticity, but it is like taking a car or taking a train -- entirely different modes of transport that achieve the ...


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Short anwer 'Non-competitive active site–binding inhibitors' are called mixed-type inhibitors. These inhibitors exhibit features of both competitive and non-competitive inhibitors, as they increase Km (like a competitive inhibitor) and decrease Vmax (like a non-competitive inhibitor). Background What an interesting question! In theory, a reversible ...


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This is a tough question. I was reading this paper Patrono, C., et al. "Clinical pharmacology of platelet cyclooxygenase inhibition." Circulation 72.6 (1985): 1177-1184. and they seemed t mention this paragraph in the introduction. Platelet Cycloxygenase or prostaglandin (PG) H synthase (i.e., the enzyme that converts arachidonate released from ...



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