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The exact mechanism is not known: Modafinil has wake-promoting actions similar to sympathomimetic agents like amphetamine and methylphenidate, although the pharmacologic profile is not identical to that of sympathomimetic amines. [...] Modafinil-induced wakefulness can be attenuated by the α1-adrenergic receptor antagonist prazosin; however, Modafinil is ...


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Yes, they can induce an acute attack. Drugs metabolised by cytochrome P450 (CYP) such as analgesics may induce acute attacks in patients with hepatic porphyrias. In recent years, preclinical and clinical studies have suggested that cannabinoid pharmaceutical preparations may be potentially useful in the treatment of pain [1]. There is even a clinical ...


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Yes, there are a few. Mostly they are designed in combination with X-ray crystallography of the target which should be inhibited. Then molecules are designed which fit specifically into these targets. The oldest example I could find is Dorzolamide which acts as a carbonic anhydrase inhibitor. See here: "Application of the three-dimensional structures of ...


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Cimbi-5 or 25i (25I-NBOMe) is a class 2C psychedelic drug.(wiki site.) Lethal dose or LD50 of "Cimbi-5" is still unknown. Though you can predict approximate the LD50 by structure computationally.


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As I recall from textbooks I read as an undergrad, one mechanism of drug tolerance works by increasing the necessary thresh-hold at a synapse such that larger concentrations of neurotransmitter or more-frequent action potentials in the upstream axon were required to depolarize the membrane and propagate the signal. Yes - usually through a reduced ...


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Though I totally agree with your views towards nanotechnology, There is always two sides of a coin. According to this article THE BAD (of Nanotechnology): Health: Nanoparticles have been shown to be absorbed in the livers of research animals and even cause brain damage in fish exposed to them after just 48 hours. If they can be taken up by ...


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From a study titled "Production of Penicillin by Fungi Growing on Food Products: Identification of a Complete Penicillin Gene Cluster in Penicillium griseofulvum and a Truncated Cluster in Penicillium verrucosum", moulds on food items were analyzed for fungi that could produce penicillin. The conclusion drawn was Among different fungal species belonging ...


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I assume you mean "why can't glutathione, NAC .. be added" From lef.org There is one problem. The FDA prohibits combining existing drugs and dietary supplements unless a New Drug Application is filed, tens of millions of dollars of clinical studies are performed, and the FDA agrees to allow the combination to be sold. The whole process can cost ...


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There's this database of genetic/drug interactions, which I think is pretty much exactly what you're looking for. Probably your best approach is to classify your drugs into a couple different categories of action. Some drugs will have to be in several categories at once(I'm lookin at you anthracyclines) Dose-dependent mutagens(cisplatin), growth-dependent ...


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Caffeine is the stimulant in tea. It has different effects on different people, but if you can sleep right after drinking it, it probably isn't strong enough to have long term 'refreshing effects', And yes, the duration of your sleep does matter. If you sleep for 12 hours, much more caffeine will filter out of your blood stream than after a 1 hour nap. ...



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