New answers tagged pharmacology
1
Since I asked this question I found out what I was doing wrong in searching for Ki (i.e. I thought the Ki ID was the test ligand and hence I was searching for drugs the wrong way) values but also how, I think Goodman and Gilman got its Ki values.
I think what they did was they searched for the hot ligand that gave the most consistent and numerous Ki values ...
2
It's important to note the difference in mechanism between cocaine and meth. While cocaine blocks reuptake, meth makes VMAT - vesicular monoamine transport - leaky and actually reverses the transportation of dopamine, so that instead of transporting dopamine into the axon terminal, it actually transports dopamine out as it leaks from the vesicle that carry ...
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