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The computational study by Ehsani et al., 2011, argues that an ancestor metal-ion transporter gene ZIP served as the initial template for the prion founder gene, where the same author produced a 2012 paper that said this was probably a product of a spliced LIV-1 ZIP transcript that became reverse transcribed and inserted into the host genome. Thus, evidence ...


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Prions are proteins that we produced but that are misfolded and affect the folding of other proteins. As we produce these proteins, we don't recognize them as antigens. If we were to recognize our own proteins as antigens, then the immune system would constantly be fighting against ourselves. This is what is called a autoimmune disease. While this was a ...


1

It is thought that infectious prions exist as clusters forming a crystalline structure. When a protein with the same primary structure is encountered but with a different tertiary structure, the normal protein undergoes a conformational change in order to integrate into the cluster. Presumably there are molecular forces involved that induce the ...



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