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Nice answer from WYS. I would have been inclined to say that the ribosome translates one polypeptide and any associations happen post translation. Insulin is interesting in that one polypeptide is produced and then cleaved to form components of the protein so that one could say multiple parts are made at the same time if I understand this correctly. ...


Are multi-chain proteins synthesized as one biological unit? Sometimes yes but mostly not. Some proteins are synthesized as one long polypeptide pre-protein which is cleaved by some proteases to yield multiple chains. After cleavage the intramolecular interactions become inter-molecular or inter-chain interactions. Insulin is a good example of this ...

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