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There is at least one known case where both the DNA and RNA versions of the same aptamer sequence bind the same target (Lauhon and Szostak, 1995). But you can't generalize this, there are two differences in structure between RNA and DNA, the Uracil/Thymine change and the missing 2'-OH in DNA. Those differences can affect the binding and overall structure of ...


Aptamers are single-stranded sequences that bind to proteins or other molecular partners. Obviously, ssDNA and ssRNA have very different (in general) binding partners. E.g. DNA is interacting with transcription factors, RNA polymerase, histones etc, while RNA is interacting with ribosomes, reverse transcriptase and others. So, shortly, it is more likely ...

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