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This is speculation, as I haven't done or read of the required experiment. However, I imagine that this would not be a problem. You're right that the RNA template (TERC) would not hybridize with a poly-G sequence, and so the telomerase would not be able to add more telomere repeats. You can imagine that the poly-G sequence is a cap, preventing telomerase ...


[ For the sake of answering a question that is long unanswered ] Can two hammerhead ribozymes simultaneously cleave each other? Yes, in principle they can. two hammerhead ribozymes simultaneously cleave each other when both are expressed, but have these ribozymes cleave a target transcript when expressed alone. This may be realized only ...

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