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Fixation is a process when one of the polymorphic alleles becomes fixed in the population gene pool due to genetic drift or natural selection and ceases to be polymorphic anymore. Therefore fixed substitution and SNP are two absolutely different concepts. So, the term “fixed single nucleotide polymorphism” seems to be oxymoron as it bears a contradiction. To ...


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In addition to the 4 nucleotide letters, there are letters that mean "the letter is one of these two or three: M = aMine = A or C R = puRine = A or G W = Weak (two hydrogen bonds) = A or T S = Strong (three hydrogen bonds) C or G Y = pYrimadine = C or T K = Ketone = G or T B = not A D = not C H = not G U = not T I would guess the the lowercase ...


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Can you provide the gene of interest? You can usually search Entrez for the gene symbol in the dbSNP database, which will pull up a NCBI Entrez page for SNPs located in the gene and will also give an indication of their clinical significance (benign or otherwise). Alternatively, if you have a specific disease in mind, you can check more specific ...



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