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In almost all metazoa, the pro-germline cells get segregated from other stem cells at an early stage of development and they thrive and differentiate in their neighborhood. This is important in order to preserve the germline. This post provides some basic explanation. However, even drosophila have adult multipotent stem cells and help in the formation of ...


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No. Very early in the development of an organism, it is just a clump of cells. Then those cells communicate, and determine where they are in the clump, which determines their eventual fate in the full organism. In mammals, for instance, cells split into three different layers, and the skin and nerve cells develop from cells in the outermost layer...etc. ...


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You have a few misconceptions about stem cells, I will try to explain where they are. First of all, cells are not independent. They influence each other with signals and secreted messenger substances. If you look at a human embryo the state of totipotency (where all cells can differentiate into each cell type of the body) ends after 3-4 days when the ...


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A skeleton is itself very complicated. It's not just apatite in the shape of a skeleton. The bones have structure, and many have bone marrow. Tiny cells navigate through the bone matrix, keeping it sound. Those cells, and the ones in the marrow, need a blood supply to keep them alive. Plus, what swbarnes2 said.


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Signalling in the TGFβ pathway normally puts a brake on the progress of cells through the cell cycle - it counteracts the action of myc for example, partly by regulating the expression of myc. In Burkitt's lymphoma myc escapes this regulation because of a chromosomal translocation, tipping the regulatory balance over to uncontrolled cell growth. This ...


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Sigma gives a solubility of 200 microMole in water containing 2% ethanol. They state: Forskolin is soluble in water (with 2% ethanol) up to 0.2 mM by first dissolving in ethanol at 5 mg/mL and doing subsequent dilutions with water. The datasheet can be found here.


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Strictly speaking ES cells are not man made, they come from blastocysts so already exist in nature. One thing you're forgetting is that even though stems cells that come from adults(experience aging) like iPS cells , they are reprogrammed to a naive or new state and thus are thought to "start all over" including getting longer telomeres(which shorten as you ...


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The transplantation is an equivalent of a process that naturally occurs in human body, homing of the hematopoietic stem cells. Immature hematopoietic stem cells have the ability to pass the bone marrow barrier, and therefore is able to migrate between bones and other organs within an individual. (e.g. thymus, which is how it can produce T cells.) Williams ...



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