Tag Info

New answers tagged

3

Codon usage optimization is still pretty much heurestic. The most common factor we think are important in E. Coli are: optimization to highly expressed genes, i.e. maximization of codon adaptation index [http://www.ncbi.nlm.nih.gov/pubmed/19359587/] keeping the optimal GC content [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0107319] ...


2

Removal of 5' cap is essential for degradation by 5'→3' exonucleases such as Xrn1/2. Xrn1/2 is constitutive and degradation of uncapped RNAs would be quite fast (don't have a reference for the exact lifetime). Deadenylation generally precedes 3'→5' degradation by exosome but I am not sure if that is a prerequisite. However tailless mRNAs can be stabilized by ...


1

I'm no expert at this but I don't think you need a Turing machine to achieve this, at least for DNA, since in conventional sense (not including carcinogenic factors such as UV) the most probable stage in which a DNA mutation can happen is during DNA replication so DNA polymerase engages in proofread to ensure accurate DNA replication, and then the DNA can ...



Top 50 recent answers are included