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What you are looking for sounds like the mechanism for a fold-change detector. I would recommend looking at these two papers: The incoherent feedforward loop can provide fold-change detection in gene regulation As an example of this working in a real system, I recommend looking at the NFkB pathway, as recently detailed by Suzanne Gaudet: Fold Change of ...


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Fishers Geometric Model (FGM) is a theoretical prediction about the adaptation process in traits. There are a number of things to establish before attempting comprehend FGM. Firstly, shifts in an adaptive landscape, in natural scenarios, are generally quite small. Because populations have been evolving for such a long time and the small shifts in adaptive ...


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Fry (2010) borrowed his variables from Kidwell et al. (1977). Kidwell defines the fitness of each genotype as, $w_{m1}$, $w_{f1}$ = male and female fitness of the A$_1$A$_1$ genotype. $w_{m2}$, $w_{f2}$ = male and female fitness of the A$_1$A$_2$ genotype. $w_{m3}$, $w_{f3}$ = male and female fitness of the A$_2$A$_2$ genotype. Kidwell then establishes ...



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