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4

I'm afraid I laughed a bit when reading that paper for the first time. Why? Well, here's what they essentially did: They tried to model evolution by implementing an algorithm. They had a population of 10000 individuals, represented by their genetic sequence, and had an algorithm do mutations of those sequences and modeled selection and reproduction to get ...

2

Probably you used bad keywords. It is called cytokine (or interleukin) network what you are looking for. There are several articles in the topic. For example: Cytokine patterns during dengue shock syndrome Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity You can find here more: ...

3

Regarding your question about whether cancer cells could be used in studying stem cells: I have done stem cell work, and we used various teratoma cell lines (which are cancers that resemble germline tissue) in parallel with embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) for various experiments. Of course the choice of ...

3

Since you are asking for the biological interpretations about these parameters, it is important to realize that the model you are presenting is a non-dimensionalized version of this model: $$\frac{dx_1}{dt} =b_1x_1\Big(1- \Big(\frac{x_1 + \beta_{12}x_2}{K_1} \Big)\Big)$$ $$\frac{dx_2}{dt} =b_2x_2\Big(1- \Big(\frac{x_2 + \beta_{21}x_1}{K_2} \Big)\Big),$$ ...

1

You just have 6 parameters in this model and you can easily perturb each of them individually while holding the others constant. This will let you know the individual effect of different parameters. To assess the global sensitivity of the system to "environmental" perturbations, what you can do is to a random multivariate sampling of parameters. You will ...

1

The base pair you are describing is only stable if each base is part of a macromolecular polymer, a polynucleotide. Specifically the DNA strands need to be oriented in an anti parallel alignment, and there will be a chain, or string, of base pairs (imagine the rungs of a ladder). Remember, individual hydrogen, or H-bonds, are one of the weakest molecular ...

6

Adding onto AMR's answer, cancer cell lines are used extensively for research. They are typically fast to grow. HeLa Long grow to capacity of a 10cm dish within about 48hours, depending how you split them. Now some lines are different than others and each have their pros/cons but the main thing behind them is they make it possible to view the effects of ...

7

Cancer cells can be and are used in cell culture. HeLa cells were the first human cell line to be grown in culture and they were derived from a cervical tumor. That being said, Cancer cell lines would not necessarily be used for stem cell work. They have sustained too many mutations to study the type of questions that stem cells are used to study, though as ...

2

John Harte's work on applying the mathematical theory of maximum entropy to ecology is certainly one of the better known examples of the application of this area of mathematics to science, in part because he literally wrote the textbook: Maximum Entropy and Ecology: A Theory of Abundance, Distribution, and Energetics (Oxford Series in Ecology and Evolution) ...

1

With detailed mechanistic models. There are a huge number of variables here, and you'll need to account for nearly all of them. Here is a similar project for crops. You could try this model for a single tree but I don't envy trying to scale that up to entire countries. Just to ballpark some figures, you could consider photosynthetic efficiency, average ...

1

Species interactions Generalities Species interact. Species actually interact a lot. One can classify species interactions into categories based on the effect that the interaction has on their fitness (≈ reproductive success). Here is a table of possible biological interactions (comes from [wiki][1]), where a + indicates "beneficial", a - indicates ...

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