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7

There is not very much transport of ions or water through the upper layer of the skin, mainly responsible for that is the stratum corneum (SC). Through this layer you will get only with small lipids and also substances which are able to penetrate the lipid layer of the cells like chloroform or DMSO. I think therefore that it is pretty unlikely that you can ...


4

The short answer is no, it will take forever for a drug to pass through skull bones. The usual reason to apply drugs on skin is if you want them to act right there, on the skin. Acne creams fit here. You need less drugs, you get where it is needed sooner, and you have fewer off-target effects, when compared to taking them by mouth. The brain is not "right ...


2

Whether a drug can be delivered transdermally? I think that carriers can be formulated to carry a small molecule through the skin into circulation, so I don't even know about lipophilicity. I believe if you spend enough money, you can overcome many of these problems. I think that pharmacology might be just as important. I think the first condition of a ...


1

I doubt it would be efficient. Your skin is a tight, water proof membrane designed to keep water and ions and other molecules inside while keeping the outside out. The molecules that are absorbed through the skin tend to be hydrophobic organic molecules. Ions, which any dissolved salt in water would become, do not easily pass through cellular membranes or ...



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