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In their active forms, various proteins have post-translational modifications (i.e. glycosylation) which are difficult to reproduce in bacteria. This is the rationale for the choice of higher organisms as the producing source. Mammalian cell lines are easier to generate and maintain but suffer from genetic and epigenetic instability (the transgene can be ...

ATryn is a human antithrombin produced in the milk of transgenic goats by GTC Biotherapeutics. It has FDA approval and I believe that it is available for prescription in the USA. Added later, after the emphasis of the question changed somewhat. Proteins produced in a mammalian system are more likely to have post-translational modifications that are much ...