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One of the main issues with nucleotide analogs is that they can also affect the host replication and transcription (though they have a higher affinity to the viral polymerase), and can therefore have adverse side effects. On the other hand, the broad spectrum anti-bacterial antibiotics specifically affect prokaryotic cellular machinery (note that some ...


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The high mutation rate is only a small part of the reason it's hard to make vaccines against those RNA viruses. The real problem is not that they mutate rapidly, but that they can tolerate high levels of variation in their antigenic regions without losing fitness. Viruses like polio and measles, as you say, have mutation rates easily on a par with ...


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From https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus: Unlike HIV-1 and HIV-2 infections in humans, SIV infections in their natural hosts appear in many cases to be non-pathogenic. Extensive studies in sooty mangabeys have established that SIVsmm infection does not cause any disease in these animals, despite high levels of circulating ...



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