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How many recombinations are required to achieve an active virus? The FDA has recognised the likelihood that lentivectors can be converted into actively replicating lentivirus if they undergo recombination with wild type HIV in a HIV positive patient. In this case, two recombination events are required to transfer the lentivector sequence into the HIV ...


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I found my answer here ISSUES RELATED TO PARTICULAR CLASSES OF VECTORS FOR GENE THERAPY http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/CellularandGeneTherapy/ucm072987.htm#vi



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