Unanswered Questions

15
votes
0answers
168 views

Was the recent “conservation hunt” of a black rhino supported by science?

CNN recently covered a sanctioned black rhino hunt in Namibia by Texan Corey Knowlton, who bid US$350,000 for the license. In the story, he claims that the hunt was actually supporting conservation of ...
11
votes
0answers
132 views

Biopython - Big Discrepancy Calculating RNA melting Temperature over Literature

I experience big discrepancies when calculating melting temperature of RNA 7-mers with Biopython over values generated by a popular algorithm. I tried the nearest neighbour algorithm with RNA and ...
10
votes
1answer
517 views

Grapefruits and CYP3A4

Grapefruit juice contains furanocoumarins, which irreversibly inhibit CYP3A4. For this reason, when one is taking certain medications it is necessary to not eat grapefruits because the inhibition of ...
9
votes
0answers
64 views

How is centriole number maintained during meiosis?

I've found a website (Pearson's BioCoach) that claims centrioles duplicate in Prophase II. Is this accurate? Does it depend on the species in question? Looking at three textbook illustrations of ...
9
votes
0answers
154 views

Do mammals develop tolerance to anticholinergics?

I know that first generation H1 antagonists, commonly known as antihistamines have anticholinergic effects. Their sedative side effects go away due to tolerance, but as for their anticholinergic side ...
8
votes
0answers
43 views

What have the L-systems (Lindenmayer systems) been actually used for in biology?

Wikipedia: An L-system or Lindenmayer system is a parallel rewriting system and a type of formal grammar. L-systems were introduced and developed in 1968 by Aristid Lindenmayer, a Hungarian ...
8
votes
0answers
88 views

Expected time for a neutral allele to reach a frequency of $p_1$ when starting at frequency $p_0$

Kimura and Ohta (1968) showed that the expected time for a neutral allele to reach fixation (given that it will reach fixation) is $$\bar t(p_0)=-4N\left(\frac{1-p_0}{p_0}\right)\ln(1-p_0),$$ where ...
8
votes
0answers
122 views

At which step apply a detection filter when preprocessing microarray data? (Before/After normalization, batch effects removal)

I am trying to understand what is the best practice when preprocessing microarray data using a detection filter (on scanner p-value). Suppose I have a microarray dataset that I have to normalize with ...
7
votes
0answers
87 views

What is the percentage of people living in England in 1500 AD whose lineage is still alive?

This sounds a bit random but it stems from a lecture in statistical genetics which I attended a while ago. We were shown a population lineage graph from which it was clear that most lineages go ...
7
votes
0answers
85 views

What is the transmembrane 'Positive-Inside Rule' nowadays? Has the definition changed over time?

First definition. Two publications by von Heijne in 1989 and 1992 coined the 'Positive-Inside rule' and showed it's practical value in topology prediction of transmembrane helices. It was clearly ...
7
votes
0answers
75 views

Selection for less efficient egg transfer in Human Botfly life cycle

I have heard that the Human Botfly transfers its eggs through other invertebrates [1], and it strikes my curiosity that if an insect could simply land on its host directly to deposit its eggs, then ...
7
votes
1answer
70 views

Reasons for the HIV-1 epidemic

So, the HIV-1 jump to humans occurred as early as the 1920s, but the AIDS epidemic didn't start until the early 1980s. Some things I don't understand about this: Why the delay? What is needed for a ...
7
votes
0answers
78 views

What is the mechanism by which lamins regulate gene expression?

The heterochromatin is generally localized at the nuclear periphery (also near nuclear lamina), whereas active genes are preferentially found in the nuclear interior. Children with ...
7
votes
0answers
81 views

How to define “Quasifixation” in continuous approximation of finite population?

Background Many models including the famous very first models derived by Sir Ronald Fisher in his early career, assume infinite population size. In an infinite population, an allele can rise in ...
6
votes
0answers
41 views

What is the fate of micronucleus DNA?

Micronuclei are cellular structures that are formed as a by-product of, usually, defective mitosis. The piece of chromosome in a micronucleus may, or may not contain a centromere and the DNA is ...

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