Unanswered Questions

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124 views
+300

Evolutionarily, why do male rats and horses lack nipples?

Developmentally male rats don't have nipples because (reddit) Testosterone release in the fetal male rat happens before the stage of mammogenesis where the teat is formed whereas other species ...
9
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0answers
332 views

Additive genetic variance components from LMER in R

I've set up some dummy data in R which makes 40 genetically related lines, they are all siblings within a line so are genetically related by a factor of ½ thus additive genetic variance should be ...
7
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0answers
34 views

Was the recent “conservation hunt” of a black rhino supported by science?

CNN recently covered a sanctioned black rhino hunt in Namibia by Texan Corey Knowlton, who bid US$350,000 for the license. In the story, he claims that the hunt was actually supporting conservation of ...
7
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0answers
71 views

Biopython - Big Discrepancy Calculating RNA melting Temperature over Literature

I experience big discrepancies when calculating melting temperature of RNA 7-mers with Biopython over values generated by a popular algorithm. I tried the nearest neighbour algorithm with RNA and ...
7
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0answers
62 views

Expected time for a neutral allele to reach a frequency of $p_1$ when starting at frequency $p_0$

Kimura and Ohta (1968) showed that the expected time for a neutral allele to reach fixation (given that it will reach fixation) is $$\bar t(p_0)=-4N\left(\frac{1-p_0}{p_0}\right)\ln(1-p_0),$$ where ...
7
votes
1answer
140 views

Circular mRNA to produce long proteins

Ribosomes can read mRNA and produce proteins, if we somehow make a circular mRNA for the ribosome to bind onto, it will make infinitely long "proteins", (since ribosomes can make very big proteins, I ...
7
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0answers
127 views

Do mammals develop tolerance to anticholinergics?

I know that first generation H1 antagonists, commonly known as antihistamines have anticholinergic effects. Their sedative side effects go away due to tolerance, but as for their anticholinergic side ...
6
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0answers
25 views

THYROGLOBULIN (19S) comes to a heavier position than ferritin (51S). Why?

Sedimentation values of thyroglobulin and ferritin containing iron are 19 and 51S, respectively. But, by density gradient centrifuge, it seems thyroglobulin(19S) migrates faster than ferritin(51S). ...
6
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0answers
29 views

What is cross-immunoreactivity, and how does it impact vaccine development?

What I understand about cross-immunoreactivity is that the antibody induced by one specific antigen is also fairly effective against another antigen. How would this be used for vaccine development? ...
6
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0answers
41 views

Basic Modelling in Quantitative Genetics

I am pretty bad in thinking quantitative genetics models. I am trying to get some basic understanding of modelling the evolution of a quantitative trait. I am therefore asking for help to analyze a ...
6
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0answers
49 views

What are the survival limitations of alcohol?

This question was inspired by watching one of the Pirates of the Caribbean movies; particularly where Jack Sparrow allegedly survives on a desert island by finding an unlimited supply of rum. I've ...
6
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1answer
76 views

Is using Hidden Markov Models to find homologues sensible in abstract, short sequences?

HMM alignment tools like hhpred excel at finding subtle homologues of folded proteins that simpler scoring techniques (such those used in BLAST algorithms) would miss. I am only looking at a small ...
6
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72 views

How to define “Quasifixation” in continuous approximation of finite population?

Background Many models including the famous very first models derived by Sir Ronald Fisher in his early career, assume infinite population size. In an infinite population, an allele can rise in ...
6
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0answers
121 views

Does Lucid Dreaming decrease the regenerative effect of sleep?

After watching this SciShow video on sleep, I wonder about lucid dreaming. Specifically: Does lucid dreaming and associated directed agency within Lucid Dreaming decrease the regenerative effect of ...
6
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0answers
108 views

At which step apply a detection filter when preprocessing microarray data? (Before/After normalization, batch effects removal)

I am trying to understand what is the best practice when preprocessing microarray data using a detection filter (on scanner p-value). Suppose I have a microarray dataset that I have to normalize with ...

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