Unanswered Questions

17
votes
1answer
763 views

Additive genetic variance components from LMER in R

I've set up some dummy data in R which makes 40 genetically related lines, they are all siblings within a line so are genetically related by a factor of ½ thus additive genetic variance should be ...
13
votes
0answers
232 views

What is the percentage of people living in England in 1500 AD whose lineage is still alive?

This sounds a bit random but it stems from a lecture in statistical genetics which I attended a while ago. We were shown a population lineage graph from which it was clear that most lineages go ...
12
votes
0answers
119 views

What have the L-systems (Lindenmayer systems) been actually used for in biology?

Wikipedia: An L-system or Lindenmayer system is a parallel rewriting system and a type of formal grammar. L-systems were introduced and developed in 1968 by Aristid Lindenmayer, a Hungarian ...
10
votes
0answers
452 views

Why don't rats have a gallbladder, unlike other rodents?

It has long been known that rats do not have a gallbladder, though other species including humans, monkeys, cows, reptiles, dogs and mice, all have a gallbladder. In this paper from almost 100 years ...
10
votes
1answer
129 views

Unilateral damage to vagus nerve

Context: The vagus nerves supply the neck viscera, heart, lungs and gastrointestinal tract. They join around the oesophagus to form the oesophageal plexus. Question: Would damage to one vagus nerve ...
9
votes
0answers
101 views

Standard practice for generating rarefaction curves from Next Generation Sequencing data

We have a few million 18S reads from a particular environment. The reads have been clustered into Operational Taxonomic Unit (OTU), and the OTUs annotated against a reference database. To generate a ...
9
votes
0answers
122 views

Selection for less efficient egg transfer in Human Botfly life cycle

I have heard that the Human Botfly transfers its eggs through other invertebrates [1], and it strikes my curiosity that if an insect could simply land on its host directly to deposit its eggs, then ...
9
votes
0answers
162 views

At which step apply a detection filter when preprocessing microarray data? (Before/After normalization, batch effects removal)

I am trying to understand what is the best practice when preprocessing microarray data using a detection filter (on scanner p-value). Suppose I have a microarray dataset that I have to normalize with ...
9
votes
1answer
139 views

Why aren't plants' roots as diverse as leaves?

I have been doing some gardening recently and I suddenly realised that all plants have superficially identical non-woody roots of the same size from gigantic trees to small fruiting plants and ...
8
votes
1answer
96 views

Primary Productivity of Oceans

80% of the world's photosynthesis takes place in the ocean. Despite this, oceans are also said to have low productivity - they cover 75% of the earth's surface, but out of the annual 170 billion ...
8
votes
0answers
282 views

Contact Inhibition of Cell Division: Signaling Pathway

The following article refers to contact inhibition of cell division in epithelial cells, specifically MDCK cells: Collective and single cell behavior in epithelial contact inhibition. In their review ...
8
votes
0answers
562 views

Evolutionary reasons why you cannot tickle yourself but masturbate

There are obviously good reasons that explain why you cannot tickle yourself (see e.g. here). This got me thinking why it is possible to masturbate... Wouldn't it make more sense to not being able to ...
8
votes
0answers
100 views

How to define “Quasifixation” in continuous approximation of finite population?

Background Many models including the famous very first models derived by Sir Ronald Fisher in his early career, assume infinite population size. In an infinite population, an allele can rise in ...
8
votes
2answers
250 views

How does LCR compare to Assembly PCR

The question pretty much explains itself. How do the two methods compare? I've always used Assembly PCR but the method is prone to mistakes and I'm curious how it compares to Ligase Chain Reaction ...
7
votes
0answers
78 views

What causes the range of severity of neurological deficits in Down's syndrome?

It's known that the severity of symptoms caused by a trisomy 21 varies from individual to individual. Part of the explanation for this range of severity is the finding that 94% of Down's syndrome ...

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