Unanswered Questions

15
votes
0answers
166 views

Phagemid display

If I'm using a bacteriophage for phage display and I'm trying to avoid avidity effects by using a helper phage what would be the best way to maintain a large library size while keeping everything ...
11
votes
0answers
80 views

Haidinger's brush: Is this a by-product of the eye's physics, or are there any evolutionary grounds for it?

The human eye is, very subtly, sensitive to the polarization of light. This is an effect known as Haidinger's brush (see Wikipedia article of this name). What, if anything, is known or at least ...
11
votes
0answers
186 views

Do the majority of fish lack scales on their heads?

Based on pictures, it seems to me that a vast majority of fish species that have scales do NOT have scales on their heads. Is that fact true? To make this properly answerable: lets' define a ...
8
votes
4answers
653 views

Does pheomelanin have a useful biological function?

Melanin is a natural pigment that is categorized into two main forms, eumelanin and pheomelanin. It's well documented in the science literature that increased eumelanin levels reduces the risk of ...
8
votes
0answers
102 views

paralogue genes in genome-wide association studies?

Has anybody tested if paralogous genes are over-represented among the genes identified by genome-wide association studies (GWAS)? For example, if a GWAS study finds 200 genes associated to the ...
7
votes
0answers
30 views

Beginning of the urogenital system

Are any invertebrate nephridia (proto/meta) homologous with vertebrate kidneys in the sense that embryologically they also begin together with the genital system? When did the embryologic association ...
7
votes
0answers
229 views

Yellow/Orange Fungus on Oak Tree

What is the fungus pictured below? The photo was taken October 6, 2013 near San Antonio, TX. I have Googled it and my results suggest Laetiporus root rot (Laetiporus sulfureus). According to this ...
7
votes
0answers
103 views

How reversible is DAT upregulation from long-term ADHD medication use?

A mechanism for ADHD stimulant medication tolerance has now been found. See http://neurosciencenews.com/adhd-medication-patient-brains-adapt-dat/. Here's the thing though: what exactly is the ...
6
votes
0answers
60 views

What are the costs associated with carrying lots of genetic material

What are the costs (if any) associated with carrying lots of genetic material? energy for copying? raw material for copying? space in the cell? Maintenance cost (matter and energy)? time to copy is ...
6
votes
0answers
133 views

Correlation between genome size and mutation rate?

Martin Nowak in his book "Evolutionary Dynamics" talks about a given correlation between genome size and mutation rate. What correlation does exactly exist between these two concepts? Is it a ...
6
votes
0answers
125 views

Do fake wasp nests actually fool wasps?

I have seen fake wasp nests sold as a deterrent against wasps and similar insects. Do they really work? Is there some scientific evidence for it? A related link: ...
6
votes
1answer
240 views

Why is membrane potential not zero at equilibrium?

For the squid giant axon, the membrane potential computed by the Goldman equation is -60mV. And the Nernst potentials are (the differences between the K+ and the Na+'s Nernst potential and the ...
6
votes
0answers
119 views

How is hibernation/aestivation different from anesthesia?

How do hibernation/aestivation happen? I read on wikipedia that a squirrel injected with the body fluids of a hibernating fellow is more prone to hibernation. If hibernation/aestivation are driven ...
6
votes
0answers
53 views

Using the IMGT/GENE-DB service to find RSS

I'm trying to get the data for the Human and Mouse 12 and 23 Recomination Signal Sequences (RSS), to run a classification algorithm on it. I'm not a biologist, so I apologise in advance for my ...
6
votes
0answers
101 views

What is the fastest way to build an alanine scanning library?

For interfacial studies, I would like to build an alanine scanning library for one of my proteins examining 20 sites. I will ultimately express the gene using E.coli cell-free protein synthesis. I ...

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