Unanswered Questions

21
votes
1answer
9k views

Where do migratory birds go when it rains?

I was reading a comic from XKCD which inspired me to ask this question: "well, where do they go when it rains?" I know that when it rains you usually don't see any birds flying through the sky. I ...
13
votes
0answers
171 views

paralogue genes in genome-wide association studies?

Has anybody tested if paralogous genes are over-represented among the genes identified by genome-wide association studies (GWAS)? For example, if a GWAS study finds 200 genes associated to the ...
10
votes
0answers
131 views

How reversible is DAT upregulation from long-term ADHD medication use?

A mechanism for ADHD stimulant medication tolerance has now been found. See http://neurosciencenews.com/adhd-medication-patient-brains-adapt-dat/. Here's the thing though: what exactly is the ...
8
votes
0answers
79 views

Using the IMGT/GENE-DB service to find RSS

I'm trying to get the data for the Human and Mouse 12 and 23 Recomination Signal Sequences (RSS), to run a classification algorithm on it. I'm not a biologist, so I apologise in advance for my ...
7
votes
0answers
147 views

What is the fastest way to build an alanine scanning library?

For interfacial studies, I would like to build an alanine scanning library for one of my proteins examining 20 sites. I will ultimately express the gene using E.coli cell-free protein synthesis. I ...
7
votes
0answers
91 views

Pancretic Acinar Cell - ATP, calcium concentration data

I need to find a decent source of data for concentration of ATP and calcium in the pancreatic acinar cell. So far all I can find is ATP or calcium 'levels' based on fluorescence , which are not ...
6
votes
0answers
80 views

Calculating additive variance, heritability, and percent of variance explained by additive effects

I've set up some dummy data in R which makes 40 genetically related lines (in this case I'm simulating hemiclones - they share one haploid copy of there genome within a line, thus additive genetic ...
6
votes
0answers
87 views

How does Sodium Valproate cause neural plasticity

I have been reading a fascinating paper: Valproate reopens critical-period learning of absolute pitch 18 individuals were given Sodium Valproate (VPA) for a fortnight during which they trained on a ...
6
votes
0answers
62 views

Are there specific features of birds that cats/small predators are attracted to?

I've recently heard a podcast, in which a professor describes one of the theories as to why we like abstract art. In his talk, he mentions an experiment with seagull chicks, in which the seagull ...
6
votes
0answers
145 views

What percentage of the total genetic variance is explained by the $n$ most important loci?

Standard models in population genetics look up at the evolution of few loci which impact fitness. The variance in fitness is determined by the genetic variance and the environmental variance (and the ...
6
votes
0answers
84 views

Neuroendocrinal mechanism of parturition

My book reads, "The fetus signals that it is mature by secreting certain hormones that diffuse across the placenta into mother's blood and cause the secretion of oxytocin from her posterior ...
6
votes
0answers
62 views

Providing small molecules to cells on a filter plate

Lets imagine that I have mammalian cells that I've immobilized on a filter. Now I want to keep providing small molecules to these immobilized cells without resolubilizing the cells. The caveat is ...
5
votes
0answers
34 views

Why can you not tickle yourself?

It's the age old question, why can't we tickle ourselves? If you rub your fingers along your skin, sure there's sensation but you don't break down into a laughing fit (at least I don't :P), if someone ...
5
votes
0answers
20 views

What's the duration between the binding of adrenaline to $\beta$-AR and the first translated protein?

Binding of adrenaline (epinephrine) to the $\beta$-Adrenergic receptor leads to formation of cAMP (via G protein activation), activation of protein kinase A and subsequently to the expression of ...
5
votes
0answers
153 views

Cytoplasmic determinants - protostomes and deuterostomes

Cytoplasmic determinants are spread unevenly in the egg, and so when embryo starts forming (cells start dividing), the determinants are also unequally divided between cell. This unequal distribution ...

15 30 50 per page