terdon

2,871 reputation

525

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	location	Marseille, France
	age	32
visits	member for	9 months
	seen	14 mins ago
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I am a computational biologist with a background in biology, not computers. My PhD work was on gene prediction and comparative genomics but my current research is in systems biology, specifically protein-protein interaction networks.

	2,871 reputation	bio	website		visits	member for	9 months
525 badges		location	Marseille, France		seen	14 mins ago

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May 6	answered	Detecting Introns and Exons
Apr 30	awarded	Notable Question
Apr 30	comment	How is gene expression estimated? @shigeta I know, I just have this graph from the conference I mentioned in my head (cannot find it) where the did a transcriptome level analysis and the correlation was pathetic. I'll find it somewhere it was a keystone meeting in Heidelberg can't be that hard to find.
Apr 30	comment	How is gene expression estimated? Wow, just found an article from 1998 stating that in yeast "We found that the correlation between mRNA and protein levels was insufficient to predict protein expression levels from quantitative mRNA data." And yet here we are, still using such data...
Apr 30	comment	How is gene expression estimated? Unfortunately I don't remember the details but I recently saw a talk in a conference where it was demonstrated that mRNA levels don't really correlate with protein levels. I mean, we've always kind of known this but the numbers shown were shocking (less than 50%, perhaps as low as 30). I will try and get a hold of a reference and post back.
Apr 30	answered	BLAST DNA Sequences Reversed
Apr 30	awarded	Nice Question
Apr 29	comment	How is it possible for animated corpses to continue their activity? @shigeta wow, thanks for making me look that up :). Care to post a question and answer it with the basics of the tetrodotoxin and the zombification process? Wikipedia is not very informative on this.
Apr 29	revised	What is the difference between orthologs, paralogs and homologs? added 1 characters in body
Apr 27	comment	What percentage of protein isoforms have different functions? Yes, that is the problem in a nutshell. Most (all AFAIK) high throughput experiments tag genes, not proteins and assign function to the gene as opposed to a specific isoform.
Apr 27	comment	What percentage of protein isoforms have different functions? Thanks shigeta but I would not call proteins coded for by different genes isoforms (and neither does the wikipedia page you linked to, it talks about alleles of the same gene). They are paralogs or orthologs depending on their evolutionary history. I would only use isoforms to describe products of the same gene. I am also assuming that most isoforms have different functions, hence my question. I am looking for data to back that assumption up.
Apr 27	revised	What light intensity starts melatonin release in humans? fixed grammar
Apr 26	comment	Why dogs move their noses when smelling? What do you mean by "3:00 to 7:00 snorted"?
Apr 26	revised	Understanding these SNP annotations deleted 5 characters in body; edited title
Apr 26	answered	Understanding these SNP annotations
Apr 25	comment	Why dogs move their noses when smelling? Might just be mechanical, note that your nose also moves if you inhale strongly enough.
Apr 23	comment	What was behind the evolution of human brain? Hi and welcome to Biologu.SU. Could you clarify your question? Do you mean what selective advantage is offered by the human brain? What makes you think it would not have been selected for?
Apr 20	comment	What are polytene bands, and why are they there? This review has more information than you will ever want to know.
Apr 17	comment	Why are there no wheeled animals? You may enjoy reading the Uplift Saga books by David Brin (quite an accomplished astrophysicist himself). They contain some of my favorite aliens in sci-fi, including the wheeled G'Kek!
Apr 17	comment	Confusion related to the use of PCA to determine the background network Could you include a bit more information on the paper so we can understand more easily?