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1920
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location United Kingdom
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From the era before Sanger sequencing was invented.


Mar
21
revised Activity of glucokinase
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Mar
19
comment How quickly is antibiotic resistance lost?
@sciencenewbie Under standard culture conditions (37C rich medium) they aren't expressed, and it is difficult to conceive of a selective advantage under conditions in which it is unnecessary to move towards nutrients. But some weak selective pressure can't be ruled out I guess.
Mar
18
answered How quickly is antibiotic resistance lost?
Mar
15
revised Would expression of GroEL and GroES in erythrocytes be a potentially effective therapy for sickle cell disease?
edited title
Mar
15
comment Would expression of GroEL and GroES in erythrocytes be a potentially effective therapy for sickle cell disease?
Apart from the answers from WYSIWYG I would add that the formation of filaments of Hb in sickle cells isn't really misfolding or misassembly, rather it is due to a new assembly pathway which results from the Glu>Val mutation. GroEL helps a protein to avoid kinetic traps en route to folding, filament formation is an extra process tacked on at the end of normal folding.
Mar
14
answered circularizing DNA molecules?
Mar
14
revised How do a viruses or bacteria survive outside the body long enough to spread?
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Mar
14
revised How do a viruses or bacteria survive outside the body long enough to spread?
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Mar
12
comment What is the minimum length required for a circular DNA ligation?
Yes, and in the last sentence the authors suggest that the exact number of base pairs will become important at these lengths: "If the number of bp in the DNA fragment is not an integral multiple of the helix repeat,then the need to twist the DNA helix in order to make strand ends meet may [make ligation difficult] for sizes less than 500bp."
Mar
11
comment From a purely biological perspective, how does an optimal human diet look?
If by "the body needs carbohydrates" you mean carbohydrates in the diet, then I disagree. We can make all of the carbohydrates that we need from other nutrients (unless you class ascorbate as a carbohydrate). This is in contrast to both fatty acids and amino acids, for which there are dietary essential species.
Mar
11
comment Does fat on our heart come from the fat that we eat?
Yes, but the pieces that are reassembled are unlikely to have been derived from the same original molecule. It must happen occasionally I guess, just by chance.
Mar
10
revised What happen's to a virus's capsid after it injects its genetic material into the host cell?
spelling
Mar
10
comment Do lysogenic viruses only infect bacteria?
This is really a question of semantics. Yes there are endogenous viruses in eukaryotic cells, but is the term lysogeny used to describe this situation in practice? (I don't think it is.)
Mar
10
answered Does fat on our heart come from the fat that we eat?
Mar
10
comment Is it impossible for a retrovirus to be lysogenic?
Are there any RNA phages that exhibit lysogeny?
Mar
10
revised What is ischaemia exactly?
edited body; edited title
Mar
10
revised Does fat on our heart come from the fat that we eat?
clarity of expression
Mar
10
awarded  biochemistry
Mar
9
answered In biosynthesis of cysteine and methionine, where does the sulfur come from?
Mar
9
revised How does a fertilized egg form 23 pairs of chromosomes?
edited body; edited title