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bio website hilbertthm90.wordpress.com
location Seattle, WA
age 27
visits member for 9 months
seen Apr 30 at 3:39
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I'm a fifth year grad student studying algebraic/arithmetic geometry.


Nov
25
comment HDL- and LDL-cholesterol
I would like to just leave this as a comment, but don't have enough reputation to do that. If you want an extremely thorough treatment of cholesterol and lipoproteins with tons of references, you should check out Peter Attia's fantastic set of 9 blog posts on the subject starting <a href="eatingacademy.com/nutrition/…;.
Aug
31
awarded  Benefactor
Aug
31
awarded  Scholar
Aug
31
accepted Biological Pathway of Lipid Hypothesis
Aug
30
comment Biological Pathway of Lipid Hypothesis
Thanks! I think of the calories in-calories out hypothesis as separate but related to the two I mentioned. If it is true, then it would make sense that a high fat diet would more easily lead to weight gain due to calorie density, but I find it hard to buy due to how closely linked how much you eat and how much you burn is. I wish the low carb trial you linked didn't have so much attrition and poor adherence. It could have shed some better light on this. It seems somewhat likely that the weight loss would continue in the long-term if people stayed on it.
Aug
30
comment Biological Pathway of Lipid Hypothesis
That second article is pretty horrible. It seems to be a survey of the literature, tons of which find no link between dietary fat and insulin resistance. Moreover, there is no proposed mechanism for why this should happen. I'll need more time to read through the first.
Aug
30
comment Biological Pathway of Lipid Hypothesis
If that is all the Lipid Hypothesis really is, then would you consider it fairly well debunked? Our modern understanding describes pretty well that the types of lipoproteins that come out of eating fat are not the type that lead to plaque on the arteries, but the type formed from eating a high carbohydrate and/or high sugar diet are.
Aug
30
comment Biological Pathway of Lipid Hypothesis
Ah. Interesting. I'm going to be a pain. I understand the Lipid Hypothesis was originally about atherosclerosis, but due to the strong correlation between obesity and heart disease most (all?) proponents of low fat diets believe that eating fat causes you to get fat. At least this is the widespread U.S. belief. So I think this has been absorbed into the modern lipid hypothesis. You will have answered my question if you point out why eating a high fat diet leads to more Leptin. I had heard that fructose causes Leptin levels to increase, but haven't seen that fat can cause it too.
Aug
30
awarded  Promoter
Aug
28
comment Biological Pathway of Lipid Hypothesis
I think my question is still unclear. It is not about how fatty acids are digested or turn into energy. I think the "Lipid Hypothesis" wasn't explained well enough. The lipid hypothesis says that there is something about eating fat that causes you to get fat, i.e. if you eat the exact same amount of calories, then eating fat will cause you to gain weight (get heart disease, etc). The carb hypothesis has a particular pathway that leads to fat accumulation that does not happen from eating fat. My question is what is a proposed pathway for the lipid hypothesis?
Aug
28
comment Biological Pathway of Lipid Hypothesis
Thanks so much for your time! Sorry if the question wasn't clear.
Aug
28
comment Biological Pathway of Lipid Hypothesis
First, nowhere in my question do I say the lipid hypothesis has no physiological basis. If so, I wouldn't ask the question. I said that defenders of the lipid hypothesis do not explain what the pathway is. Second, this explains (as you point out) how lipids are catabolized which I already knew. I'm wondering what the proposed pathway from ingesting fat to fat accumulation is, not how fatty acids are turned into an energy source. It would also be nice for people who stumble on this to be able to read an answer if you understand this rather than dig through a Wikipedia article to find it.
Aug
27
awarded  Student
Aug
27
awarded  Supporter
Aug
27
asked Biological Pathway of Lipid Hypothesis
Aug
27
awarded  Autobiographer