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May
29
awarded  Yearling
Apr
16
awarded  Notable Question
Jun
24
awarded  Popular Question
Jul
27
accepted How does formaldehyde cause protein-DNA crosslinking?
Jun
24
accepted Transcriptionally-mediated DNA damage
Jun
20
comment Transcriptionally-mediated DNA damage
That's a good point about actin and GAPDH. My understanding is that tightly packed heterochromatin is more "stable" than euchromatin because it is energetically favorable to remain wrapped around histones. Additionally, the conformation induced by the DNA/histone coil prevents many of the nucleotides in heterochromatin from being exposed to the nucleoplasm, which would decrease its exposure to DNA damage agents compared to uncoiled euchromatin.
Jun
19
asked Transcriptionally-mediated DNA damage
Feb
3
revised How does formaldehyde cause protein-DNA crosslinking?
Fixed typo
Feb
3
asked How does formaldehyde cause protein-DNA crosslinking?
Sep
27
accepted How can chromatin state be measured?
Sep
24
asked How can chromatin state be measured?
Sep
12
awarded  Scholar
Sep
12
awarded  Supporter
Sep
12
accepted Digital Genomic Footprinting for ENCODE
Sep
12
comment Digital Genomic Footprinting for ENCODE
This is very helpful. I didn't understand what "random shearing" was, or how it would add error to the results. If I'm understanding correctly, random shearing during processing of DNA is unlikely to generate fragments that are relatively short (300 bp), which means that the 300 bp fragments are, with high probability, coming from short segments of DNA that have been clipped by DNase twice.
Sep
11
awarded  Student
Sep
11
awarded  Editor
Sep
11
revised Digital Genomic Footprinting for ENCODE
Clarification of question
Sep
11
comment Digital Genomic Footprinting for ENCODE
The section in bold is what's confusing me. The rest is provided as context.
Sep
11
asked Digital Genomic Footprinting for ENCODE