Bitwise

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	1,031 reputation	bio	website		visits	member for	8 months
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Apr 13	comment	The oldest common ancesstor of all human beings Isn't that Adam? ;)
Apr 10	comment	Where to put the gene after eukaryotic promoter for best expression levels? Eukaryote is rather general - different eukaryotes have vastly different regulatory systems. Are you talking about something like human or something like yeast?
Apr 8	comment	Differences Between Protein Motifs and Protein Domains? @WYSIWYG thanks for the clarification, I was going to mention structural motifs but forgot to write it.
Apr 8	comment	Is it possible to make bacteria vulnerable to antibiotics it's resistant to? @dd3 Sorry about that, I misread the question. I will edit it slightly and will keep it just since it might be useful for someone.
Apr 1	comment	What is the gas inside a Capsicum pepper, and how does it get there? +1 for the scientific experiment
Mar 29	comment	Least painful way to die Should we be worried?
Mar 21	comment	E. coli values for [enzymes], [metabolites] and kinetic rates I found SABIO: sabio.h-its.org
Mar 9	comment	Are all chromosomes equally susceptible to mutation? Are you asking about the mutation rate with or without the effect of selection?
Mar 9	comment	Is it possible to do chip-seq on a specfic region? Are you interested in doing this in vivo or in vitro (by in vitro I mean adding the factor to naked dna and then crosslinking)? In what species?
Feb 22	comment	Polymerase Observations I suspect this is homework, so I will give you a hint (I hope I understand the question correctly). Think about the following: Do you think all the functions of the polymerase are performed by the same set of amino acids? What is the relation between 1D and 3D structure?
Feb 13	comment	What is the advantage of circular genomes for bacteria and linear genomes for other organisms? @AlanBoyd related to the discussion below regarding replication speed, it is interesting to note that B. burgdorferi has a very slow doubling time of 12-18 hours.
Feb 12	comment	What is the advantage of circular genomes for bacteria and linear genomes for other organisms? @MCM this might be a bit off topic, but I wonder if a linear genome really requires condensation into chromatin. If it was the same DNA content as the circular uncondensed genome why would it need to be packed? are there examples of species with linear genomes that are not packed into chromatin (bacteria/archea)?
Feb 12	comment	What is the advantage of circular genomes for bacteria and linear genomes for other organisms? @MadScientist good point, I hadn't thought about that. Still, if you take a eukaryote like a yeast, it seems to manage with telomeres and with having a relatively short cell cycle time (~twice that of E coli). So I am still not sure that speed or not having telomeres are a sufficient advantage.
Feb 8	comment	What is the advantage of circular genomes for bacteria and linear genomes for other organisms? While I agree with your answer, the question remains why don't the bacteria have linear genomes also, since it is very easy to create linear genomes. My guess is that a circular genome might be easier to replicate faster, since eukaryotes typically have longer cell cycles. Anyone else have ideas about that?
Feb 1	comment	Why is the Hydra Biologically Immortal? @mysky I added a link to the Wikipedia article on telomerase, which has much of this information included. I don't know if you call that "reliable" though and what technical level you would like.
Jan 2	comment	Simulating Cell differentiation Note that the data is actually stored not only genetically (in the DNA sequence) but also epigenetically (e.g. modified chromatin).
Dec 3	comment	Can children restore brain cells? @nico here is one relevant reference I found: brain.oxfordjournals.org/content/126/3/556.long
Nov 6	comment	What triggers creative thought in humans? So you mean creativity?
Oct 26	comment	A mathematician's confusion regarding parametric $t$ tests for gene expression data @leonardo sounds fishy... as I said, I wouldn't take this as an example of good data analysis. Although I believe that in the time since that paper was published some aspects of analysis in biology papers have become better, including multiple test corrections.
Oct 25	comment	What's the name of the fibrous strands that hold the seeds in a pumpkin? I have also found some sources that suggested this is the placenta, but couldn't find a good example like a figure with an arrow pointing to that and saying "placenta". Googling "pumpkin placenta" gives bubkes.