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521
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location Cambridge, United Kingdom
age 29
visits member for 2 years, 4 months
seen Apr 14 at 8:43

I’m a bioinformatics PhD student at EMBL-EBI and the University of Cambridge but I’m originally from Berlin.

I’m mainly working on genomics using next-generation sequencing data. My current thesis project is about the regulation of tRNA expression in mammals.

Here’s my …

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Sep
17
comment Does DNA contain information beyond protein synthesis?
@Alan It absolutely is. The interaction is shown in vivo. The debate over whether this binding performs a function (and the definition thereof). Whether functional or not, it is, at some point or other, bound to – either by transcription factors or transcription machinery (i.e. transcribed). Ewan says exactly that in the blog post you linked, and he even qualifies his use of the word “functional”.
Sep
16
comment Does DNA contain information beyond protein synthesis?
@S.RobertJames I don’t know. I would guess that most (though obviously not all, e.g. mitochondria / chloroplasts) organelles could also form de novo since their constituents are once again coded for in the nuclear genome and their assembly might again be either spontaneous or aided by other proteins. In fact, a friend just reminded me of things like centrioles which require a helper protein for assembly.
Sep
16
revised How are antibodies designed?
edited title
Sep
16
comment How are antibodies designed?
@Alan I didn’t. Nico added that word. I was actually interested in in vivo route. I think nico also meant the same (I wasn’t even aware that there was another route) and simply wanted to stress that they are designed.
Sep
16
answered Does DNA contain information beyond protein synthesis?
Sep
16
asked How are antibodies designed?
Sep
13
comment How are the boundaries of a gene determined?
Just to clarify: we’re talking about protein-coding genes here, right? There are many more for which the methods are completely different.
Sep
13
comment Have proteins been observed to come into existence through mutations and natural selection?
The “real time” requirement is an incompatible criterion with the rest. It’s designed to make this question essentially unanswerable.
Sep
9
comment Microbiome Data
Purely computational questions are better suited for biostars.org
Sep
9
answered Is DNA mutation locally energetically stabilizing the DNA molecule
Sep
8
awarded  Cleanup
Sep
8
revised Robotic surgery for treating cancer?
rolled back to a previous revision
Sep
6
awarded  Nice Answer
Sep
5
comment Is “computational biology” different from “bioinformatics”?
I don’t think this definition is commonly agreed on. Where we work, most people are self-proclaimed bioinformaticians (heck, we even have it in the institute’s name) but according to this answer they’d be classified as computational biologists. They may also do the latter (because the topics are usually intrinsically linked) but the focus is definitely biological study, not development of tools.
Sep
5
comment What is the Edward O. Wilson fuss about?
@Abe I’m not an expert but as far as I know none of those actually requires group selection. Many phenomena are simply explainable by kin selection. And while we don’t have comprehensive explanations for large-scale phenomena such as religion etc., you can construct potential explanations without invoking group selection. Indeed, just because there’s interaction within and between groups involved doesn’t mean that evolutionary selection happens on the level of groups, just like genetic selection doesn’t happen on the level of individuals, it happens on the level of alleles.
Sep
4
comment What is a focal copy number variation?
You could probably even call an aneuploidy (variation in chromosome number) a CNV. So that’s pretty large-scale.
Sep
4
revised What is the Edward O. Wilson fuss about?
Speling & grammer. Duh.
Sep
3
answered What is the Edward O. Wilson fuss about?
Aug
30
comment Evolutionally speaking, why do humans have 46 chromosomes
@nico Sure. What I meant was: given that our close ancestors had a different number of chromosomes, when/why did it change? That’s an interesting question, and essentially what OP is asking.
Aug
30
comment What kind of fruit is this?
So you can eat it? Damn, I wasted my childhood! I always walked by such a tree but was too afraid to try.