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Jun
23
comment What type of distribution should binding affinities fit?
@kmm Ki values have to always be >0, yet normal distributions normally give a high probability for Ki values <0 and hence the normal distribution is something I'm wondering whether I should discard. It depends on the drug and receptor target too so I would like a nice and general answer if possible. I find that the kstest usually comes up for a p<0.1 that it fits a normal distribution so it might, but the negative values do concern me.
Jun
23
asked What type of distribution should binding affinities fit?
Jun
12
answered How do you average Ki values?
May
19
revised What effect do oligosaccharides, like those found in legumes, have on the composition of intestinal flora in humans and if so how so?
added 3 characters in body
May
16
revised What effect do oligosaccharides, like those found in legumes, have on the composition of intestinal flora in humans and if so how so?
edited title
May
16
asked What effect do oligosaccharides, like those found in legumes, have on the composition of intestinal flora in humans and if so how so?
May
2
asked What does “Activation” refer to in the context of the symptoms of Schizophrenia and Schizoaffective Disorder?
Apr
30
comment How do you average Ki values?
The latter would be a breach of copyright and the other I don't quite understand how that would be better.
Apr
30
revised How do you average Ki values?
added 81 characters in body
Apr
30
comment How do you average Ki values?
Nope, all the units are nM.
Apr
30
revised How do you average Ki values?
added 226 characters in body
Apr
30
asked How do you average Ki values?
Apr
22
accepted Which Enzymes Catalyse the Deacetylation of Drugs in the Human Body?
Apr
22
asked Can Infant Crocodiles digest Bread?
Apr
21
awarded  Critic
Apr
19
revised What's a good and reliable database on the pharmacodynamic and pharmacokinetic data of drugs both approved and unapproved?
added 3 characters in body
Apr
19
answered What's a good and reliable database on the pharmacodynamic and pharmacokinetic data of drugs both approved and unapproved?
Apr
17
comment What's a good and reliable database on the pharmacodynamic and pharmacokinetic data of drugs both approved and unapproved?
Where exactly on this site do you find the PD and PK data? I looked up sertraline all I got was these sort of pages...accessdata.fda.gov/scripts/cder/drugsatfda/…
Apr
17
asked What's a good and reliable database on the pharmacodynamic and pharmacokinetic data of drugs both approved and unapproved?
Apr
17
asked What's the mechanism of action of Levomepromazine's analgesic effects?