948 reputation
1316
bio website en.wikipedia.org/wiki/…
location Townsville, Australia
age
visits member for 1 year, 10 months
seen Sep 5 at 22:30

Sep
25
comment Are there any online resources one can use to access raw clinical trial data without having to contact those involved in the study?
I most certainly have not; thanks!
Sep
15
comment Why can't sodium butyrate be delivered orally in humans and other mammals?
@shigeta Na, I doubt it seeing how corticosteroids tend to taste terrible (which thing I know from personal experience as an asthmatic) and yet we have methods of getting around this problem such as putting them into capsules or telling the patients to just suck it up.
Sep
11
comment Why are Taurine and Arginine essential components of the feline diet?
Oh and for me to accept your answer regarding Taurine I am going to need something to back that up I saw that article before you mentioned it but I wanted something more scholarly than wikipedia
Sep
11
comment Do Total Gastrectomies leave individuals more open to infections from eating unsanitary food?
Yeah I think so too that's why I even asked the question -- to confirm what makes sense.
Sep
11
comment Why are Taurine and Arginine essential components of the feline diet?
Arginine is not essential for adult humans. Cats and dogs probably (I don't know for certain but I'm guessing) require arginine because of its crucial role in the urea cycle and their high rate of ammonia production as a result of amino acid catabolism for energy production.
Sep
9
comment Other than Acetylcarnitine what other orally-bioavailable Acetyl donors exist to assist in the conversion of CoA to acetyl-CoA?
You have a good point but it would be just exquisite if you could find some evidence to support the idea that a significant amount of these acetyl-CoA's are used by histone acetyltransferase and thus influence gene expression.
Sep
4
comment Where can I find an at least Semi-Comprehensive list of what biochemical reactions Acetyl-CoA participates in?
Are these reactions solely those that occur in the human body?
Jul
2
comment What Effect would Cannabinoids have on the Acute Porphyrias?
Sort of, I know they can interact with the P450 cytochromes and hence may bring on an acute attack.
Jun
23
comment What type of distribution should binding affinities fit?
@kmm Ki values have to always be >0, yet normal distributions normally give a high probability for Ki values <0 and hence the normal distribution is something I'm wondering whether I should discard. It depends on the drug and receptor target too so I would like a nice and general answer if possible. I find that the kstest usually comes up for a p<0.1 that it fits a normal distribution so it might, but the negative values do concern me.
Apr
30
comment How do you average Ki values?
The latter would be a breach of copyright and the other I don't quite understand how that would be better.
Apr
30
comment How do you average Ki values?
Nope, all the units are nM.
Apr
21
comment What are the conditions that must be satisfied in order for drugs to be deliverable via the epidural route?
This question is about general drugs. If you're asking about pentazocine it is a predominantly kappa opioid.
Apr
17
comment What's a good and reliable database on the pharmacodynamic and pharmacokinetic data of drugs both approved and unapproved?
Where exactly on this site do you find the PD and PK data? I looked up sertraline all I got was these sort of pages...accessdata.fda.gov/scripts/cder/drugsatfda/…
Apr
16
comment Which receptor in particular does, “MUSCARINIC CHOLINERGIC” refer to in Goodman and Gilman?
@dd3 OK, here are the relevant tables.
Apr
13
comment How does Tianeptine work to elicit its therapeutic effects?
Just wondering if there are any additional theories.
Apr
6
comment How can homosexuality evolve despite natural selection?
@rg255 you're right.
Mar
27
comment How can homosexuality evolve despite natural selection?
Yep, neither do I have any problem. The purpose of asking this question I think is to detach any prejudice because evolution implies genetics and thus a lack of control over said orientation.
Mar
25
comment Why do some people find vegetables so repellent when evolutionarily they should find them an attractive and thus tasty food?
OK I appreciate your honesty, for that I will leave it open and unaccept your answer, but I will also upvote your answer.
Mar
25
comment Why do some people find vegetables so repellent when evolutionarily they should find them an attractive and thus tasty food?
A healthy diet is also more likely to result in us being more healthy and thus looking more attractive to potential mates so it still seems odd that the foods that are among the richest in said vitamins are so repugnant to us.
Feb
14
comment What's the therapeutic index of Pethidine (Meperidine in the US)?
Sounds about right. I've been trying to get a pharmacy stackexchange site started but that's going to take at least a few months even if it gets a relatively large amount of support.