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location Singapore
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visits member for 1 year, 5 months
seen 8 hours ago

University of Kansas - Genetics of stem cell maintenance

Genome Institute of Singapore - RNA regulatory networks

University of Washington - Cell and tissue programming


9h
comment How many different protein coding genes are in the Human Biome?
@WYSIWYG I think I would consider the same gene found in two different microbe species to be different as they operate within a different genomic environment. But I'm not sure. I imagine that there is a lot of mutualistic sharing of gene products between microbes, and probably some horizontal gene transfer as well. The answer I'm most looking for is some quantification of genetic and molecular information.
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accepted How many different protein coding genes are in the Human Biome?
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comment How many different protein coding genes are in the Human Biome?
This is what I'm looking for. Thanks @Chris
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comment How many different protein coding genes are in the Human Biome?
"360x more abundant than human genes" looks like a good answer. So, probably millions of genes.
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comment How many different protein coding genes are in the Human Biome?
Thanks @Devashish I tried to clarify the question. I hope it makes more sense. And no, the genes do not have to be known to affect the human genome; they just need to be resident.
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revised How many different protein coding genes are in the Human Biome?
edited for clarity
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comment How many different protein coding genes are in the Human Biome?
If I had to guess, I'd estimate there are at least hundreds of thousands of different protein-coding genes associated with a human.
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comment How many different protein coding genes are in the Human Biome?
These look like numbers for the human genome only.
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comment How many different protein coding genes are in the Human Biome?
Yes, I'm asking how many different genes are associated with a human and its resident symbionts, i.e. the number of protein-coding genes in the human genome + the number of protein-coding genes in the human microbiota.
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comment How many different protein coding genes are in the Human Biome?
Sorry, I mean only the human microbiome.
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revised How many different protein coding genes are in the Human Biome?
edited title
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asked How many different protein coding genes are in the Human Biome?
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comment How to bring back to life a dead body?
Can you define life also? Is consciousness required?
2d
accepted What are some atypical examples of positive transcriptional cooperativity?
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comment What are some atypical examples of positive transcriptional cooperativity?
The Polycomb/Trithorax system looks like it does exhibit cooperative activity. Thanks for the reference. I found this one also: nature.com/nrm/journal/v15/n5/full/nrm3789.html Specifically, the last section and fig. 7 where the authors propose that Polycomb/Trithorax Response Elements, found in target enhancers, promote bistability in target expression. Thanks!
2d
comment High frequency human genetic oscillators?
Natural, and the simpler (fewer parts) the better. I'm looking for an endogenous oscillator that can be coupled to synthetic circuits.
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answered How did the horned lizard evolve?
Jul
21
comment How much divergence would be needed for classifications as astrobiology?
Are you asking how long an organism must live in a non-earth environment before it is considered astrobiological?
Jul
21
comment What are some atypical examples of positive transcriptional cooperativity?
I do see that the activity described in these papers requires binding between the different factors, but I do not see where they measured cooperativity. I think there is some confusion about what cooperativity means. I'm specifically referring to cooperativity of biochemical binding that results in a non-linear response. en.wikipedia.org/wiki/…
Jul
21
comment What are some atypical examples of positive transcriptional cooperativity?
Can you explain or propose (or reference to) the underlying mechanism for polycomb/trithorax cooperativity? Thanks.