552 reputation
37
bio website github.com/sopo
location Paris, France
age 25
visits member for 2 years, 4 months
seen Mar 2 '13 at 11:09

PhD student in Paris.

Working on the crosstalk of glucocorticoids and thyroid hormones at a genome wide level during the metamorphosis of the Xenopus tropicalis tadpole.

I also have some knowledge in bioinformatics, more precisely in processing and analysis of NGS data.


Dec
20
comment How are the boundaries of a gene determined?
@nico : Ok, I see your point, but I don't think the OP had this definition of a gene in mind. Also, I totally agree that new technologies such as RNA-seq give you a more comprehensive answer for genome annotation.
Dec
20
comment How are the boundaries of a gene determined?
@nico : so, with the definition you provide, a gene has no boundaries.
Dec
18
comment Are single-celled organisms capable of learning?
Just a note: qualifying a species of "lower organism" could make some purist cringe ... I dont have a straight answer, but you might be interested in this paper which describes a model of event memory in amoeba
Dec
16
comment What histological stain can I use for beta-keratin?
After a quick search, it seems that many people working on beta keratin use specific antibodies. Yet it appears that you could use toluidine blue, but I'm not sure about the specificity regarding alpha/beta keratin.
Dec
16
comment Bacterial chromatin binding data?
Thanks for the reference, I'll read that with great interest !
Dec
15
comment Bacterial chromatin binding data?
Well, a byproduct of the fact that prokaryotes do not have nucleosomes, is that they don't have chromatin either. Compaction is achieved through supercoiling of the genophore. Do you mean binding of a protein to prokaryotic DNA ?
Dec
15
comment What are the mechanism binding histone code with alternative splicing?
Thanks for editing the link.
Dec
15
comment Transmission of epigenetic regulation through surrogate mother
You are totally right, for some reason histone variants did not come to my mind when answering :)
Dec
15
comment What are limiting factors for intron length?
I don't know about the maximum length, but I suppose that for the minimal size, the mechanical properties of the DNA are the limiting factors. Under a certain size, DNA is simply too stiff to form the loops required during splicing.
Dec
15
comment Bacterial chromatin binding data?
I'm not sure I fully get your question. Prokaryotes do not have nucleosomes.