2,495 reputation
523
bio website flavors.me/randogp
location Lausanne, Switzerland
age
visits member for 1 year, 3 months
seen 1 hour ago
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PhD in Pharmacology. My pet molecules are called nuclear receptors and I do research with them studying the relationships between nutritional messengers and gene expression. My preferred technique is bioluminescence imaging, and I love to use it with new reporter gene approaches.


May
16
comment Is wiping with RNAse Zap enough to destroy RNAse activity?
The MSDS reports to contain only a 'trade secret' surfactant in the range 1-20%. Why you say it is not a detergent?
Apr
23
comment Why is yawning contagious?
Are you looking for a causative factor (i.e, a neural circuit connects external yawing cues to the internal yawning effector center) or are you interested in the physiological/evolutionary reason (i.e., yawning communicates hypoxic environment to other individuals in the nearby).
Apr
19
comment PEG-silane treatment: why incubate for 18 hours at 60 degrees Celsius?
Google Images: glass chemical structure
Dec
5
comment What are the advantages and disadvantages of using beta-galactosidase compared to luciferase as a reporter gene?
Here a list of other luciferase assay shortcomings.
Nov
3
comment Do omnivore mammals vary food preferences based on dietary needs?
not sure amino acids can be considered micronutrients like vitamins.
Nov
1
comment Is there any biological reason that professional swimming is dominated by white people?
+1 the question is not racist, but I suggest to edit the question and replace 'race' with 'phenotype'. I'm sure there is a good cultural explanation, but this does not rule out genetic basis: Asian people get drunk easily because of the DNA. Looking forward for a GWAS study of olympic players: it will be very interesting!
Sep
24
comment Is there sufficient evidence that human cells are not intelligent?
something you would need to clarify is your definition of intelligence
Sep
21
comment Is there any documented evidence for suicide among vertebrates other than humans?
I would be curious to check if unicellular organisms commit apoptosis.
Sep
8
comment Does red light preserve your night vision?
For the negative votes: thanks. I edited the answer to be more on target.
Sep
1
comment Biological Pathway of Lipid Hypothesis
In biology, 'all' does not exist. You may better figure out that some 'excess' fat is accumulated in WAT, some 'excess' in stool, some 'excess' in atheromas etc...
Jun
21
comment How high is the energy yield of photovoltaics compared to photosynthesis?
@David. Thanks, fixed the point: of course energy can not be produced/created. My curiosity indulges in the application: could we ever use plants for domestic energy requirements?. It seems photovoltaic are much better, do you agree?
Jun
13
comment Pipetting damage on cells
Artem is right: the only way to say is empirically. The P1000 will influence the cell damage likely because of the velocity. In contrast, the P200 and P20 could give some damage due to the narrow tip hole.
May
14
comment How to store vegetables in the refrigerator: In plastic bags or not?
You may want to make a scientific experiment with your own fridge. That would be the most authoritative source for your own conditions. Just split the same veggies in two groups (with or without bag) and consume them after few days. Replicate the experiment at least three times. If you find differences, you have the evidence. If you don't find differences, forget the conundrum and make peace with your wife.
May
11
comment Is there any difference in terms of personal healthcare between complete DNA sequencing and SNPs genotyping?
Not my field, but I guess most DNA methylation and other epigenetic modifications would be organ specific. I wonder if a buccal swab could give useful information in this context.
May
9
comment How do nuclear receptors locate each other to form a DNA loop?
Not sure NR are actually bending a linear DNA into a loop. The loop, as Shigeta points, could already form by random coiling. Then, NR would stabilize the loop recruiting other coregulators. All together they will act like a glue.
May
4
comment Finding exons in DNA problem
look at the polyA which is added after transcription and follow 3'-->5'. The first nucleotide after the polyA is a G then G then A. Can you find back them in the DNA? Yes? As soon as you find a correspondance between the RNA and the DNA you are in the last exon. When the correspondance is lost, you are in a intron, when the correspondance get back, you are in the following exon.
May
4
comment Why do men have nipples?
@Shep: Preece and Armatus are right, 'default' refers to sex determination. At the beginning of development, the cells have bipotential state. Then, the Sex-determining Region of the Y chromosome (SRY gene) express a transcription factor that initiates male development. In absence of Y chromosome, the human embryo develops as 'default' into a female.
May
3
comment Does red light preserve your night vision?
@Shep 1) sorry I'm not aware about consequences on night-vision, are companies selling red lamps claiming improvements on night-vision? 2) Red light is the only one passing through our tissues, but lamps are used after sunset when you are still awake.
Apr
28
comment Automatic cropping of collimated digital X-ray images
I think ImageJ is actually the best option. You can pay a freelance developer to write the macro for you: it does not seems a big task the way you describe it
Apr
26
comment Do any animals other than humans undergo menopause?
Especially if peri-menopause killer whales have mood swings...