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May
15
comment What is the difference between a mechanistic and a statistical predictive model?
@PaulBarr I can't write MWE for those, since mechanistic models are usually complex...also I don't have the time. Sorry.
May
15
comment What is the difference between a mechanistic and a statistical predictive model?
@PaulBarr Usually, you can simulate the mechanistic model, but often difficult to fit its parameters from data. To build the mechanistic model, it is often necessary to make assumptions about the dynamics and parameters which are not strongly supported by data.
May
15
comment What is the difference between a mechanistic and a statistical predictive model?
@PaulBarr I think you are missing the point. If you had the appropriate data, you can always use statistics to answer the how question. Mechanistic models sometimes don't have that luxury, and are pieced together from partial knowledge from here and there. Statistical modeling exploits the observed variables, in my example, those would be only the drug administration and the heart rate.
May
11
comment Why is the brain dependent on glucose?
I don't have a clue, but just plausible ideas: (1) amino acid or lipid processing is more dangerous or hinders function. Neurons need to survive for a life time. (2) the rate at which neurons need to regulate their energy level requires fast modulation, and only glucose can do it.
May
5
comment Neural coupling between Pinsky-Rinzel (reduced Traub) neuron with a Wang-Buzsaki neuron?
By "action potentials" you mean the pattern of firing, not the shape of the action potential itself? Also, what's driving these neurons?
May
5
comment Neural coupling between Pinsky-Rinzel (reduced Traub) neuron with a Wang-Buzsaki neuron?
your first link to Pinsky and Rinzel is invalid. Try linking DOI or the abstract page.
May
3
comment Feeling of spicy
What is cooling doing exactly to the perception here? Any references that would support your claim?
Apr
28
comment Oscillatory electrical system using a chain of neurons
I vote to re-open this (edited) question. At least there are some theoretical studies on such systems, and also relation to how such constructions can't explain the scalar property.
Apr
13
comment Supercomputer Vs Human Brain
In my opinion this is a much better answer than Devashish Das (OP)'s answer which got 15 up votes and is chosen as an answer at the moment.
Apr
2
comment Is it possible for a human to wake up in a wrong way?
do you have references for this "feel different" claim?
Mar
24
comment Is there a biological neuron that spikes in response to hyperpolarizing currents?
Search for "rebound excitation" or "rebound spiking".
Mar
2
comment Are all dinosaur bones radioactive?
Here's one theory: truthisscary.com/2012/05/…
Mar
1
comment Why sigmoid curves appear in quantitative analysis of many biological phenomena?
Tons of examples in psychophysics and neuroscience...
Feb
28
comment if the load is removed from an eccentrically contracting muscle, will it start contracting concentrically?
It is not clear to me what you are asking.
Feb
27
comment What (open) software there are for simulating behaviour of human (cortical) neurons?
Sure, you can regularize your solution, and put extra constraints to get a better solution, but do you really recover the behavior of the cortical neurons with a thousand dipole model? Are dipoles the right representation for neural computation? We don't know the answer, but I'm betting they are insufficient.
Feb
27
comment What (open) software there are for simulating behaviour of human (cortical) neurons?
Perhaps I misread OP's question. Upon re-reading, OP only says "simulating the behaviour of human cortical neurons", I guess it could be larger scale model. I'm editing my answer.
Feb
27
comment What (open) software there are for simulating behaviour of human (cortical) neurons?
Thanks for the feedback! Yes, of course you can do source localization, assuming there are a few dipoles (or under other simplifying assumptions), but it's difficult to connect to the neuronal level simulation as the OP wants to do. (Sorry. I don't know how to turn your answer into a comment.)
Feb
20
comment What is an auditory upward sweep?
It just means a sound that starts at a low frequency and goes up to higher frequency like a whistle sound. Perhaps someone can give you an example sound file and/or a spectrogram representation of it.
Feb
13
comment What actually are thoughts?
But what are thoughts? :) I don't think the question is well defined yet. If you indicate a specific "thought" or "thought process" in mind, you may get a better answer.
Feb
6
comment Why aren't circadian rhythms exactly 24 hours long?
Perhaps because the optimal cycle of life is not 24 hours due to seasonal changes and migrations? It is quite difficult to make biological oscillators with very long periods precise, and it doesn't need to be, because one can entrain an oscillator with external stimuli. And as you mentioned in the comments, variations can be helpful in many ways.