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visits member for 2 years, 5 months
seen May 2 '13 at 21:15

Apr
16
comment Mechanics of going from DNA sequence to metabolic network
Still a few open questions, but I think that gives me enough to start doing more focused background work. Thanks!
Apr
16
awarded  Scholar
Apr
16
accepted Mechanics of going from DNA sequence to metabolic network
Apr
13
awarded  Supporter
Apr
13
comment Mechanics of going from DNA sequence to metabolic network
Many thanks for getting this started. I understand (or least have an intuition about) everything after "... and that structure dictates function"; and I've wandered through the KEGG database. So maybe the question is better phrased: How is the protein structure determined/predicted from the protein-coding portion? (I think this is the 'reconstruction' part?) Thanks again for you patience. (I should add that I'm not immune to doing my own digging; a few pointers in the right direction would be appreciated.)
Apr
13
comment Mechanics of going from DNA sequence to metabolic network
The long Question is how to predict a function. To try to be more specific, I've tracked down the paper by A. M. Feist, M. J. Herrgård, I. Thiele, J. L. Reed, and B. Ø. Palsson, “Reconstruction of biochemical networks in microorganisms,” Nat Rev Micro, Feb. 2009. I'm trying to dig into Figure 1.
Apr
13
comment Mechanics of going from DNA sequence to metabolic network
Yeah, I was afraid of that. I was looking for a very introductory level bit of material(s) and was hoping that someone had put something together. I'll understand if you close the question.
Apr
13
awarded  Student
Apr
12
asked Mechanics of going from DNA sequence to metabolic network