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Apr
12
comment Relationship of the DNA of a eukaryotic gene to the 5'-UTR of its mRNA
Hi @David - maybe I've also misunderstood something but the exons by definition are the translated regions, therefore would not be part of the UTR (un-translated region). On the diagram you can see there is a long stretch of sequence between the start of the mRNA (the cap) and the "coding sequence" i.e. the exons (bear in mind introns have been removed by this stage so all included exons appear together). -- user137 that would be interesting, and I expect it would affect pre-mRNA processing to some degree.
Apr
6
comment Relationship of the DNA of a eukaryotic gene to the 5'-UTR of its mRNA
Thanks for accepting it so quickly - I've updated it some more as I realise it was quite long and hadn't quite answered you question. Included more info on the promoter aspect. :)
Apr
6
comment Runs of homozygosity - degree of inbreeding and disease associations
Thanks @Remi.b will have a look
Oct
2
comment Why do adult insects have 6 legs?
As it stands I agree with @fileunderwater -- this is a question about evolutionary advantages. However, if you were to make this question about the various functions that insects put their "legs" to then it is no longer a "duplicate" of that question. Even if this question is closed as a duplicate, you can edit it and it can be reopened :)
Aug
29
comment What is pQTL and why do we need eQTL?
The amounts of protein and mRNA are correlated, if not directly proportional. I understand what you are saying, that changes in the amount of mRNA do not necessarily equate to a change in protein abundance, but it seems quite logical to me that if a SNP either changes the mRNA sequence, or changes the abundance of the mRNA, the SNP could affect the amount of protein - this will differ in every case of course, and pQTLs that have been documented presumably do alter the final protein (either in form or abundance), otherwise they would not be reported as pQTLs.
Jul
15
comment What fraction of sites are expected to be polymorphic?
While this link may answer the question, it is better to include the essential parts of the answer here and provide the link for reference. Link-only answers can become invalid if the linked page changes.
Jul
15
comment Does mixing alcoholic drinks really make you more drunk?
Thanks, but you have not actually provided an answer for the question asked: "Does mixing alcoholic drinks really make you more drunk?"
Jun
30
comment Why do some medicines induce sleep?
Hi - I agree with some previous comments that this is too broad because (and this is an assumption) the mechanisms will probably differ between medicines - if you have a few in mind then list them in the question and this will hopefully be answered (I am very interested to see an answer - particularly for antihistimines I take around this time of year... makes me very groggy some days)
Jun
29
comment Can you recharge without sleeping?
Ok. Didn't realise that reference was for all the points due to the vague wording - my apologies, it is an interesting answer.
Jun
29
comment Can you recharge without sleeping?
Hi, this is a well-written answer, but can you include a few references (e.g. that lack of sleeps would kill you sooner than lack of food). Thanks!
Jun
29
comment Can you recharge without sleeping?
Hi Marc - this has received a number of close votes because personal medical questions, or questions relating to your own personal health, are considered off topic. To make this "on topic" just remove the references to your own situation, therefore any answers/recommendations cannot be misconstrued as personal medical advice (which the vast majority of people here are not qualified to give). Thanks!
Jun
11
comment
Thanks! At what is now the University of Exeter Medical School - what was the Peninsula Medical School. "Genomic epidemiology" with Prof David Melzer & Prof Lorna Harries. I have been here since 2006 (for my undergraduate degree) - and you?
Jun
10
comment
I will try not to let the fact you went to Exeter (where I have just got my PhD) bias my voting!
Apr
2
comment Is it possible for a human to wake up in a wrong way?
I think the "sleep inertia" you refer to is the reason - if you are woken by your alarm during a particular cycle of sleep this would have an effect lasting all day [haven't looked this up - anecdotal]. This would then be referred to as having woken up on the wrong side of the bed (which is just a saying not a literal reason why you are having an off day). Could be due to all sorts of reasons though, including nutrition, recent physical activity, stress, alcohol/drug consumption... etc!
Mar
23
comment Is using Hidden Markov Models to find homologues sensible in abstract, short sequences?
Hi there - seems like you may get an answer from someone on BioStars or another site with more computational/statistical expertise - as this question is not really biological per se, more bioinformatic
Mar
19
comment Obvious phenotypic inheritance markers in humans
Interesting question. Eye and hair colour (two "obvious" ones), to my knowledge, can be different from either parent due to the dominant/recessive nature of alleles. I would be interested to know of any "true" <trait characteristic>, as you put it
Feb
27
comment Can DNA & RNA be considered as nature's programming language?
Hi @a.aniq I have made some edits to your question, to give you an idea of how a question might be structured (i.e. remove anything subjective - clarified meaning); but there are still massive assumptions that you made that I have left in - if you do a little research to clarify your own understanding and substantiate some of your assumptions with sources this question may qualify for re-opening and one of us can provide you with a much more detailed answer :)
Feb
26
comment What software/approach to use to build a graph based on microarray gene expression correlation?
Hi @VassiaAlk - Cytoscape is pretty well designed for constructing a "network" of genes that are connected by their degree of correlation in expression; check out the online resources (e.g. apps.cytoscape.org/apps/expressioncorrelation). This site is aimed at biological questions, therefore this is off topic. Best
Feb
18
comment Can DNA & RNA be considered as nature's programming language?
... there is more at work than simply the DNA. This field of regulation and differentiation concerns epigenetics, which are modifications to the DNA that do not change the genetic sequence, and is to some degree hertiable. Therefore it is incorrect to say that DNA alone makes an organism, and it is incorrect to say that other fields of biology are just beating around the bush - there are many more factors at play than just the genetic code.
Feb
18
comment Can DNA & RNA be considered as nature's programming language?
Was literally just writing an answer :/ in my eyes there is nothing opinion-based about this (although the question could be phrased better): classical molecular biologay says DNA makes RNA makes Protein. Whilst this is true, less than 2% of the genome is protein-coding, with the rest coding for regulatory regions and non-coding RNA molecules (often with important functions of their own). So whilst in some respects DNA could be considered the 'code' for organisms, it is much more complicated than this: each cell of an organisms has the same genetics but different phenotypes, so clearly ...