shigeta

11,722 reputation

939

bio	website	affymetrix.com/analysis
	location	Berkeley, CA
	age	49
visits	member for	1 year, 5 months
	seen	39 mins ago
stats	profile views	133

PhD structural biology. I do bioinformatics for Affymetrix in the SF bay area. Interested in systems / synthetic biology, expression analysis and machine learning.

	11,722 reputation	bio	website	affymetrix.com/analysis	visits	member for	1 year, 5 months
939 badges		location	Berkeley, CA		seen	39 mins ago

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May 17	comment	Why do Humans not produce Vitamin C like other mammals? Interestingly Linus Pauling thought that this was a fundamental defect in animals and that vitamin supplements could restore human health against disease and illness. Characteristically he wrote a book about vitamins and started the dietary supplement industry as we know it today. Uncharacteristically, he was probably wrong about how much vitamins we need.
May 17	comment	Why is polyploidy lethal for some organisms while for others is not? Diploidy is an adaptive regulatory mechanism that is not necessary to multicellular life. Plants and cancer cells are notriously unregulated in ploidy count.
May 17	comment	How to find ion/water channel related genes i'm afraid a literature crawl is the only reliable way to get domain knowledge like this.
May 17	comment	Can protein structure be determined by X-Ray Diffraction in a single image? @Mad Scientist comment started running long, edited answer..
May 17	revised	Can protein structure be determined by X-Ray Diffraction in a single image? added 905 characters in body
May 17	comment	Can protein structure be determined by X-Ray Diffraction in a single image? I think that while they are working very hard, the X-ray laser and cryo EM reconstruction doesn't yield as consistant a set of results as crystallography. when the proteins just lay on a surface, they can be shape distorted, and so recombining the images makes can be difficult to interpret.
May 17	answered	Question: Annotation search in scientific literature
May 16	answered	Why is PEG important for efficient yeast transformation?
May 16	answered	What risk to DNA does long-term exposure to low-dose radiation pose?
May 16	answered	Why are some plants frost tender?
May 16	comment	How does one calculate the resolution of a crystal structure? Resolution is a general metric, the quality of the x-ray structure, describing the amount of data collected for the structure. The quality of the structure depends on how well the structure reproduces the data collected.
May 16	comment	How does one calculate the resolution of a crystal structure? Yes- The resolution is a result of the mean coherence of the crystal; if its disordered on the 2 angstroms, then the resolution peters out at that diffraction angle. There are cases where diffraction in one direction is stronger or weaker than in other directions. Such anisotropic resolution is not unusual and is described pretty literally "crystal diffracts to 4Angstroms along the a axis and 3Angstoms otherwise.
May 16	awarded	Revival
May 16	answered	Does GFAJ-1 use Adenosine triarsenate as its energy currency?
May 16	awarded	Revival
May 16	answered	How does one calculate the resolution of a crystal structure?
May 15	awarded	Revival
May 15	answered	How do Proteins migrate in MES vs. MOPS
May 14	comment	How do Proteins migrate in MES vs. MOPS these are non denaturing protein gels (No SDS)?
May 14	revised	Solution based measurement of Solvent-Accessible Surface Area of macromolecules added 129 characters in body