shigeta

11,687 reputation

939

bio	website	affymetrix.com/analysis
	location	Berkeley, CA
	age	49
visits	member for	1 year, 5 months
	seen	5 hours ago
stats	profile views	133

PhD structural biology. I do bioinformatics for Affymetrix in the SF bay area. Interested in systems / synthetic biology, expression analysis and machine learning.

	11,687 reputation	bio	website	affymetrix.com/analysis	visits	member for	1 year, 5 months
939 badges		location	Berkeley, CA		seen	5 hours ago

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5h	comment	How to use mechanical microstrainer to extract tissue proteins from human? what is a micro strainer? is this an idea you have or a reference to a specific piece of equipment? several methods of the sort you have described may be used, but i've not heard of a microstrainer...
14h	comment	Is local equilibrium a reasonable assumption for evolutionary processes? You are right - overall the environment, which is always subject to change puts individuals in dynamic equilibrium. See the Red Queen hypothesis. The genome itself is never completely at equilibrium either.
2d	comment	How is transport of glucose into prokaryotic cells different from transport into eukaryotic cells? Interestingly, bacterial and eukaryotic glucose transporters are similar in structure, though bacteria do not have insulin. ncbi.nlm.nih.gov/pubmed/23075985
May 14	comment	Why do ants dig surface paths? I wonder if this might be an extension of nest-building behavior. the dirt that runs along both sides of the path looks like debris from nest cleaning.
May 14	comment	Why is a slow worm not considered a snake? the defining factor is that the species definition comes from where they species has come from, not only its body plan. In fact the slow worm has features in its body plan that more resemble lizards than snakes. The species name is as much a reflection of the history of that animal as it is a description of what may look like.
May 14	comment	How is the exogenous DNA protected from degradation during bacterial transformation? As an aside, one of the reasons that plasmids are circular no doubt is to prevent natural degradation of the sort you are talking about.
May 11	comment	Which X-Y chromosomes have the developmental genes for mammals? There are surveys of such genes from mouse studies, my favorite is MEST. I took a shot at that one @dd3 :)
May 10	comment	How long can a naked human survive on Mars? You have a point RhysW, it sort of depends on whether you are talking about the most extreme conditions, average , or what.
May 10	comment	How long human can survive with just drinking water everyday nice find... I imagine the average is a bit lower than this, but the record kind of tells you how long we can endure without food if we're well hydrated and not otherwise stressed.
May 10	comment	Exercise causes number of cell divisions to approach Hayflick limit faster? And hence shorten life expectancy? Athletes who work too hard can actually shorten their lives, but for the most part exercise does prolong one's life. Neither of these effects probably have to do with the Hayflick limit tho.
May 10	comment	Exercise causes number of cell divisions to approach Hayflick limit faster? And hence shorten life expectancy? I think there's another point here that the cells repaired do not divide and so the tissue in general does not have cell division as a result of exercise. Even healing from injury probably has a minimal impact in this regard as well.
May 9	comment	Does biofuel production by microalgae need an extra source of CO2? Thanks, both! I think we'd still need power plants to convert the biofuel to energy (unless its bioelectricity or biohydrogen). With a projected population of 12 billion, demand for fuel is just going to go up. I think they were saying that from the plants/factories you can pump the CO2 directly into the pools of algae. I'd like to see numbers on how this might prevent the CO2 from getting into the atmosphere. Could help... we used to bubble CO2 into the algae in the lab to help it grow. I would be surprised if it changed the efficiency of an effort this size by more than a few %..?
May 9	comment	How long can a naked human survive on Mars? good point - big difference between sunlight and day/night conditions, but there is a limit to how quickly the body can lose heat....
May 9	comment	How long can a naked human survive on Mars? the time to death after being submerged in ice water is not that short. I'd say asphyxiation (< 5 minutes) would do it first. This is kinda a bar-bet conversation... but still interesting.
May 8	comment	Why are certain aneuploidies more common? this is still quite a likely explanation - there is very little or no data for pregnancies that terminate before the foetus is smaller than a pea. Almost all extra chromosomes for instance come from sperms and ova formation and they may simply not compete for fertilization.
May 8	comment	Is there any recent evidence for the aquatic ape theory of human evolution? Article in the Guardian by an Editor of Nature on this: guardian.co.uk/science/occams-corner/2013/may/07/… I wouldn't say this theory is creationism, but it does not have the weight of any evidence behind it, which is necessary for evolutionary theories.
May 8	comment	Recent and good quality articles on systems biology Maybe we could start with asking for a list of the most interesting problems currently being worked on in systems biology... what do you think Mattia?
May 7	comment	How are zooids identified? yes - its a bit of a fantastic a way of describing it, but does distinguish them from animals with a specific digestive and circulatory system.
May 5	comment	Looking for detailed nutrient/energy flow at the bottom of the freshwater food chain Ecological modeling literature is where I'd look - who has done this before ... or going into a well-funded graduate program might be a good way to go. ;)
May 4	comment	What is the oldest example of DNA identified? I rather think that if the proper chemical conditions can preserve the molecules within tissue, you can find very old DNA. In this case the bacteria were preserved in crystalized salt and this seems to have kept the DNA intact. Other examples are from insects preserved in amber and tissues from animals who were buried in permafrost.