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1d
comment Do both Carbamazepinum and Lamotriginum increase glutamate threshold?
I added my summary about those drugs in the body: group, mechanism of action and Indications. Do you agree? I do not know if I can write so many indications if then the mechanism of action is enough general. I am very uncertain about the groups. CYP-450 inductor does not sound good in the first drug.
1d
comment Do both Carbamazepinum and Lamotriginum increase glutamate threshold?
In lamotrigine, only in vitro studies about GABA here pubchem.ncbi.nlm.nih.gov/compound/… The exact mechanisms of both these systems are not known. How would summarize this?
1d
comment Do both Carbamazepinum and Lamotriginum increase glutamate threshold?
It says it may involve GABA A/B in the mechanism of action here pubchem.ncbi.nlm.nih.gov/compound/… What do you think?
1d
comment Do both Carbamazepinum and Lamotriginum increase glutamate threshold?
What do you think about this? Block Na+ ion channels and inhibit glutamatergic neurotransmission stimulating GABA and balancing neuronal excitation and inhibition. I try to make a short one-linear about their common general functioning.
May
24
comment Can systemic intravascular thrombosis cause brain infarction?
@RoryM Feel free to do so and add relevant references to your answer.
May
23
comment Can systemic intravascular thrombosis cause brain infarction?
@WYSIWYG Thank you for your comment! I was very young in this field when I first time thought about this issue. I extended my answer little by adding some relevant sources.
May
23
comment Can systemic intravascular thrombosis cause brain infarction?
It would be great if you can add references to your answer.
Mar
12
comment Is Sinus node conduction necessary for heart beating?
@AtlLED Define properly. Clearly, the ejection fraction will be less than in the normal case.
Jan
28
comment Speed of effective lymphatic drainage?
@JasandPruski We need technical tools to evaluate the speed of lymphatic drainage that is to investigate the flows of liquid phases and energy transfers. This is a part of Soft Matter Physics where the leading books are 1) Hamley - Introduction to Soft Matter, 2) Intermolecular Surface Forces by Israelachvili, 3) Giant molecules - here, there and everywhere. Still, these books do not cover the topic fully only provide some tools. You have to do the computation and visualisation yourself. I am actually doing a course about this topic called "Soft Matter Physics" in Aalto University right now.
Jan
21
comment How can succinylcholine cause myorelaxation?
So the short answer to my question is that the succinylcholine cause myorelaxation because of cholino-receptor antagonism with big dose or second dose; stimulated by endocytes and degradation of the cholinergic receptors.
Jan
21
comment How can succinylcholine cause myorelaxation?
What is the event called that causes such a phenomena as phase 1 block and phase 2 block? Do other adrenoergic drugs and Cardiac drugs have such characteristics? How such an event documented for instance in PubChem, for instance in the link in the body of my question? I want to be aware of such events for each drug.
Jan
14
comment What does irregular heartbeat mean in simple language?
Again one more delete request but also 1+ more upvote. I put the explanation to the introduction why I focus on my answer on the nature of the device, why it gives subjective results, how it could be redesigned for objective results and why conclusions based on subjective measurements are subjective.
Jan
14
comment How is the nasal secretion system of local immunity coupled with lymphatic circulation?
@WYSIWYG Thank you for your question! This sentence was introduced by one leading researcher in the field last year in London. I contacted him about your question. I hope I can provide it to you.
Jan
13
comment Does transplanted heart have full sympaticus without medication?
Downvoter! Leave, a feedback.
Jan
11
comment What does irregular heartbeat mean in simple language?
@Tivie Yes, I agree with you that implications are one part here. I want to make it super clear that there is no connection subjective measurement and giving such indications based on them. This is one reason why I want to emphasize first the subjectivity of the device, and let the reader understand why. Without mentioning and explaining that everything that comes can be problematic. I also describe a device which can more objectively do the analysis in blood pressure monitors. There is no BP device in market which can objectively analyse all irregular heartbeats with little false negatives.
Jan
10
comment What does irregular heartbeat mean in simple language?
@Tivie Mate, you have a subjective device and you are making conclusions based on such measurements. Also, deductions of irregular heartbeats based on such devices are much more subjective. This is my point! You should not provide health advice here and particularly not health implications based on subjective recordings. My point is to provide understanding why you cannot do this and the OP understands this by showing acceptance of the answer.
Jan
10
comment What does irregular heartbeat mean in simple language?
@Tivie Yes, you are right. Arrythmias are rarely benign. I get an interpretation that there is a risk of going into tachycardia in your answer: "Some arrythmia are physiological" and then you describe situation tachycardic processes as arrythmic which is not necessary. This I call overloading which can confuse.
Jan
9
comment What does irregular heartbeat mean in simple language?
@RoryM Please, make a summary about your feedback and send them to me if you can. You assert and exaggerate without giving concrete examples. You say you search something without results. I suspect your skills of searching appropriate sources. Do you really imagine that you can find this kind of information what I wrote here in any internet site or book? It is at a cross-section of many fields which can make it challenging. You underestimate me. I repeat that this SE site is not for medical advice. To take shortcuts is not the way go in research. You ignored the explanation of the Bounty.
Jan
9
comment What does irregular heartbeat mean in simple language?
@dustin This forum is not for medical advice! I do not even write such answers here. This is for understanding in Biology which means real world and living organism. This requires understanding. Yes, I understand how the question comes. To explain how the measurement result comes is one point here - it is just an approximation from the machine which can have many designs. To explain the main question in the title is another thing too. Third thing is about indications. 4th thing is about implications from subjective results which should not be made, since this is not for medical advice!
Jan
9
comment What does irregular heartbeat mean in simple language?
@dustin Last sentence is arrogant in your comment. The question has many parts. Some answers have focused here on explicit implications. This thread should be split in many parts to answer it completely. Heartbeat, how the device detects it and what the irregularity of the heartbeat mean.