Timeline for New ORFs occurring in SARS-CoV-2 due to mutations
Current License: CC BY-SA 4.0
5 events
| when toggle format | what | by | license | comment | |
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| Oct 22, 2021 at 12:35 | comment | added | Sir Cornflakes | I appreciate this answer although I hadn't really asked for it, because it broadens my view on the virus genome of SARS-CoV-2. I am still interested in more answers, describing situations for SARS-CoV-2 like the one exemplified by @reuns' comment for the original SARS virus. | |
| Oct 21, 2021 at 20:31 | comment | added | bob1 | @reuns ORF8a/b was identified in SARS-CoV (the original one) so I don't think this is a new thing at all for CoV-2, which is what the question was about. | |
| Oct 21, 2021 at 18:49 | comment | added | bob1 | @reuns - Why don't you post that as an answer yourself. The reason I posted this is because they genuinely do produce new putative ORFs all the time because of the quasispecies thing. However, a new ORF does not necessarily produce a functional protein or may alter the function (e.g. decrease expression) of a functional ORF, so you end up with non-functional or less functional particles that don't lead to anywhere in evolution terms. | |
| Oct 21, 2021 at 15:51 | comment | added | reuns | I don't really see how it is related to the question. Please take a look at the ORF8 deletions in SARS, in particular the 29nt deletion present in the main epidemic strain but not in some earlier strains, causing a much shorter ORF8 protein, named ORF8a, and a new ORF8b ORF overlapping the end of ORF8a in a different frame. In the early strain ncbi.nlm.nih.gov/nuccore/AY390556.1 the long ORF8 is called ORF10-11 and in the epidemic strain ncbi.nlm.nih.gov/nuccore/NC_004718.3?report=genbank there is ORF8a and ORF8b | |
| Oct 21, 2021 at 7:31 | history | answered | bob1 | CC BY-SA 4.0 |