Timeline for Can typed-switched B cells recognize the tertiary structure of antigens?
Current License: CC BY-SA 4.0
10 events
| when toggle format | what | by | license | comment | |
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| Jul 23, 2022 at 0:41 | review | Close votes | |||
| Aug 9, 2022 at 3:02 | |||||
| Jun 30, 2022 at 3:23 | vote | accept | Rand | ||
| Jun 30, 2022 at 3:23 | answer | added | Rand | timeline score: 1 | |
| Jun 30, 2022 at 3:20 | comment | added | Rand | Ah, didn't realize that b cells endocytos BCR-bound antigens and present on MHC class 2.. makes sense. | |
| Jun 20, 2022 at 18:04 | comment | added | Rand | Sorry, meant antigen, typo.. how does the Th cell know it recognizes the same antigen as the B cell (or vice versa)? | |
| Jun 20, 2022 at 16:18 | comment | added | MattDMo | Th cells are not "specific to the same antibody" as B cells because T cells don't care about antibody/BCR recognition sites. B cells are activated by Th cells that recognize the same antigen (a protein, for example), but not the same epitope. BCRs/antibodies and MHC (I or II) have very different epitopes. A B cells Class II doesn't necessarily display the same peptide its BCR recognizes. | |
| Jun 20, 2022 at 2:37 | comment | added | Rand | But doesn't it take a Th cell specific to the same antibody as a B cell to cause the B cell to type switch? And the Th is immune restricted to class II MHC. | |
| Jun 20, 2022 at 0:23 | comment | added | MattDMo | MHC and B cell receptors/antibodies are totally different things, and recognize completely independent antigens. I think you're mixing up the two. | |
| Jun 19, 2022 at 2:24 | history | edited | Rand |
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| Jun 18, 2022 at 22:30 | history | asked | Rand | CC BY-SA 4.0 |