Timeline for Random X-Inactivation and Duchenne
Current License: CC BY-SA 4.0
9 events
| when toggle format | what | by | license | comment | |
|---|---|---|---|---|---|
| Feb 27, 2023 at 16:12 | comment | added | Rommelaar | Thanks for your elaboration! | |
| Feb 26, 2023 at 16:13 | comment | added | E Tam | Random/ stochastic just means that the event is non-deterministic. As long as we are talking about probabilities we are describing a random process. The uniform distribution, where every outcome is equally likely, is not more random. The lottery is random and there are only two outcomes (you win or you lose), but that does not mean you have a 50-50 chance of winning. No matter what the probability of a carrier for Duchenne has for will presenting the disease, that fact we are describing the process with probability means that we are describing a random process. | |
| Feb 26, 2023 at 11:30 | vote | accept | Rommelaar | ||
| Feb 26, 2023 at 11:30 | comment | added | Rommelaar | Having read your comment again, I think it brings me closer to an understanding. I'm gonna do some more reading on non-random X inactivation. Thank you! | |
| Feb 26, 2023 at 7:32 | comment | added | Rommelaar | Thank you for your elaboration, my question is about naming, I think. I understand the process of (skewed) x-inactivation, in principle, but the thing that's not clear is why it's called random inactivation if only a few % of carriers express the disease phenotype. If it would be truly random, 50% of carriers would express the phenotype, as one chromosome at random gets silenced. This probably has to do with dominance, but I find it a bit counterintuitive and would like to know a bit more about this. | |
| Feb 26, 2023 at 4:44 | history | edited | E Tam | CC BY-SA 4.0 |
added 2473 characters in body
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| Feb 25, 2023 at 6:11 | comment | added | Rommelaar | Would it be helpful if I rephrase to include the relation between X inactivation and dominanc? | |
| Feb 25, 2023 at 5:17 | comment | added | Rommelaar | Thank you for your answer, my question was more about the seemingly confusion naming of (non) random X inactivation | |
| Feb 24, 2023 at 19:13 | history | answered | E Tam | CC BY-SA 4.0 |