Timeline for What's the longest transcript known?
Current License: CC BY-SA 3.0
5 events
| when toggle format | what | by | license | comment | |
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| Sep 16, 2014 at 0:30 | comment | added | canadianer | I don't have a reference for this, but I was told by a professor once that a long developmental gene is Drosophila takes longer to transcribe than the length of the cell cycle during initial development so that is not actually expressed until the cell cycle lengthens later in development. That's perhaps one answer (if uncommon) to the question of why some genes are so long. | |
| Sep 15, 2014 at 23:06 | comment | added | user137 | Cases like this make me wonder why alternative splicing would be worth it. If you divide 2.4 million bases by 14000 bases you get 171.4. Seems like you could just make multiple copies of dystrophin to cover all the isoforms and still save space, and only need to transcribe the copy you want. Evolution should have gotten an engineering degree. | |
| Sep 15, 2014 at 22:28 | comment | added | shigeta | alternative splicing is a wierd thing to be sure. biology is not rational but then human science has not yet produced a living cell from first principles... | |
| Sep 15, 2014 at 22:26 | comment | added | user137 | why does it transcribe 2.4 million bases and cut it down to 14,000? Seems like a waste of time and energy, not to mention the potential for mutations, which if muscular dystrophy is any clue, would be deadly. | |
| Sep 15, 2014 at 22:02 | history | answered | Chris♦ | CC BY-SA 3.0 |