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Drake's Law. What is thisthe genome-wide mutation rate and what are the estimates?

Drake's rule

Drake's rule states that the genome-wide mutation rate is more or less constant across all species — from E.coli to the house sparrow.

Data

From what I think being Drake's original paper (table 1, page 4) on the subject (see here) is at the order of $3\times 10^{-3}$. When I look at this paper, I see that the genome-wide mutation rate is roughly around 30 for human. When I look at this paper, they cite some other papers suggesting a genome-wide mutation rate in the order of 0.1 to 1 in multicellular eukaryotes and typically at the order of 1 for vertebrates. Finally, when I look at this speech (at the 60th minute), it seems however that the genome-wide mutation rate in human is 2.2.

What is going wrong?

Do I mix-up different concepts or are there some very contradicting estimates depending on the article we look at? Isn't the genome-wide mutation rate, $U$, which is just the number of de novo mutations transmitted to one offspring on average? What is a correct estimate of $U$ for human for example (1, 2.2 or 30)?

Drake's Law. What is this genome-wide mutation rate?

Drake's rule

Drake's rule states that the genome-wide mutation rate is more or less constant across all species — from E.coli to the house sparrow.

Data

From what I think being Drake's original paper (table 1, page 4) on the subject (see here) is at the order of $3\times 10^{-3}$. When I look at this paper, I see that the genome-wide mutation rate is roughly around 30 for human. When I look at this speech (at the 60th minute), it seems however that the genome-wide mutation rate in human is 2.2.

What is going wrong?

Do I mix-up different concepts or are there some very contradicting estimates depending on the article we look at? Isn't the genome-wide mutation rate, $U$, which is just the number of de novo mutations transmitted to one offspring on average?

Drake's Law. What is the genome-wide mutation rate and what are the estimates?

Drake's rule

Drake's rule states that the genome-wide mutation rate is more or less constant across all species — from E.coli to the house sparrow.

Data

From what I think being Drake's original paper (table 1, page 4) on the subject (see here) is at the order of $3\times 10^{-3}$. When I look at this paper, I see that the genome-wide mutation rate is roughly around 30 for human. When I look at this paper, they cite some other papers suggesting a genome-wide mutation rate in the order of 0.1 to 1 in multicellular eukaryotes and typically at the order of 1 for vertebrates. Finally, when I look at this speech (at the 60th minute), it seems however that the genome-wide mutation rate in human is 2.2.

What is going wrong?

Do I mix-up different concepts or are there some very contradicting estimates depending on the article we look at? Isn't the genome-wide mutation rate, $U$, which is just the number of de novo mutations transmitted to one offspring on average? What is a correct estimate of $U$ for human for example (1, 2.2 or 30)?

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Drake's rule

Drake's rule states that the genome-wide mutation rate is more or less constant across alall species — from E. coliE.coli to the house sparrow.

Data

From what I think being Drake's original paper (table 1, page 4) on the subject (see here) is at the order of $3\cdot 10^{-3}$$3\times 10^{-3}$. When I look at this paper, I see that the genome-wide mutation rate is roughly around 30 for human. When I look at this speech (at the 60th minute), it seems however that the genome-wide mutation rate in human is 2.2.

What is going wrong?

Do I mix-up different concepts or are there some very contradicting estimates depending on the article we look at? Isn't the genome-wide mutation rate, $U$, which is just the number of de novo mutations transmitted to one offspring on average?

Drake's rule

Drake's rule states that the genome-wide mutation rate is more or less constant across al species from E. coli to the house sparrow.

Data

From what I think being Drake's original paper (table 1, page 4) on the subject (see here) is at the order of $3\cdot 10^{-3}$. When I look at this paper, I see that the genome-wide mutation rate is roughly around 30 for human. When I look at this speech (at the 60th minute), it seems however that the genome-wide mutation rate in human is 2.2.

What is going wrong?

Do I mix-up different concepts or are there some very contradicting estimates depending on the article we look at? Isn't the genome-wide mutation rate, $U$, which is just the number of de novo mutations transmitted to one offspring on average?

Drake's rule

Drake's rule states that the genome-wide mutation rate is more or less constant across all species — from E.coli to the house sparrow.

Data

From what I think being Drake's original paper (table 1, page 4) on the subject (see here) is at the order of $3\times 10^{-3}$. When I look at this paper, I see that the genome-wide mutation rate is roughly around 30 for human. When I look at this speech (at the 60th minute), it seems however that the genome-wide mutation rate in human is 2.2.

What is going wrong?

Do I mix-up different concepts or are there some very contradicting estimates depending on the article we look at? Isn't the genome-wide mutation rate, $U$, which is just the number of de novo mutations transmitted to one offspring on average?

Source Link
Remi.b
Remi.b
  • 68.3k
  • 11
  • 144
  • 235

Drake's Law. What is this genome-wide mutation rate?

Drake's rule

Drake's rule states that the genome-wide mutation rate is more or less constant across al species from E. coli to the house sparrow.

Data

From what I think being Drake's original paper (table 1, page 4) on the subject (see here) is at the order of $3\cdot 10^{-3}$. When I look at this paper, I see that the genome-wide mutation rate is roughly around 30 for human. When I look at this speech (at the 60th minute), it seems however that the genome-wide mutation rate in human is 2.2.

What is going wrong?

Do I mix-up different concepts or are there some very contradicting estimates depending on the article we look at? Isn't the genome-wide mutation rate, $U$, which is just the number of de novo mutations transmitted to one offspring on average?