The 3C (chromosome conformation capture) technology for studying chromatin 3D organization starts by a cross-linking step using formaldehyde to find segments of DNA interacting. In my understanding the cross-linking happens ONLY between the DNA and proteins forming a DNA-protein-DNA complex.

Can formaldehyde cross-link two double stranded DNA molecules? Is the 3C approach also capturing direct DNA-DNA interactions?

I looked at the literature, especially Dekker et al. description of the method, but couldn't find this information. Thanks.

The 3C (chromosome conformation capture) technology for studying chromatin 3D organization starts by a cross-linking step using formaldehyde to find segments of DNA interacting. In my understanding the cross-linking happens only between the DNA and proteins forming a DNA-protein-DNA complex. The "only" is from a DNA stand-point as of course protein-protein cross-links will also occur.

Can formaldehyde cross-link two double stranded DNA molecules? Is the 3C approach also capturing direct DNA-DNA interactions?

I looked at the literature, especially Dekker et al. description of the method, but couldn't find this information. Thanks.

The 3C (chromosome conformation capture) technology for studying chromatin 3D organization starts by a cross-linking step using formaldehyde to find segments of DNA interacting. In my understanding the cross-linking happens ONLY between the DNA and proteins forming a DNA-protein-DNA complex.

Can formaldehyde cross-link two DNA molecules? Is the 3C approach also capturing direct DNA-DNA interactions?

I looked at the literature, especially Dekker et al. description of the method, but couldn't find this information. Thanks.

The 3C (chromosome conformation capture) technology for studying chromatin 3D organization starts by a cross-linking step using formaldehyde to find segments of DNA interacting. In my understanding the cross-linking happens ONLY between the DNA and proteins forming a DNA-protein-DNA complex.

Can formaldehyde cross-link two double stranded DNA molecules? Is the 3C approach also capturing direct DNA-DNA interactions?

I looked at the literature, especially Dekker et al. description of the method, but couldn't find this information. Thanks.