Timeline for Where does the lactate produced by tumors go?
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| Nov 13, 2017 at 17:34 | comment | added | Roland | @becko I'm not aware of any quantitative data on how much lactate is re-oxidized in tumors. But given that respiration yields 10--15 times more ATP than glycolysis for the same amount of carbon, it seems that a large population of purely oxidative cells would be needed re-oxidize all surplus lactate from glycolytic cancer cells. And again, there is plenty of data showing that tumors generally produce lactate. (In some cases even causing life-threatening acidosis: ncbi.nlm.nih.gov/pmc/articles/PMC4497494 ) | |
| Nov 13, 2017 at 16:52 | comment | added | a06e |
"But it seems unlikely that this can remove a major fraction of lactate produced by glycolytic tumors, since glycolysis produces lactate at a much higher rate than respiration consumes it" Has this been measured/estimated?
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| Apr 13, 2016 at 13:27 | vote | accept | a06e | ||
| Feb 7, 2016 at 17:47 | comment | added | a06e | I guess I'm not expecting to find a general answer. But at least some references in the literature would be nice. The papers you point out are already useful. | |
| Feb 7, 2016 at 0:50 | history | answered | Roland | CC BY-SA 3.0 |