Timeline for Deviation from Hardy Weinberg equilibrium (HWE)
Current License: CC BY-SA 4.0
9 events
| when toggle format | what | by | license | comment | |
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| Jan 7, 2021 at 18:19 | answer | added | Roger V. | timeline score: 2 | |
| Jan 7, 2021 at 6:56 | review | Close votes | |||
| Jan 22, 2021 at 3:07 | |||||
| Jan 6, 2021 at 18:11 | comment | added | Maximilian Press | @Vadim ok, that makes sense. I agree with your overall point about p-values used to confirm the null hypothesis, I think I was just worried about the other side of the issue, which wasn't clear. I think that you actually addressed the question quite directly and accurately! I would suggest making it into an answer, actually. | |
| Jan 6, 2021 at 8:26 | comment | added | Roger V. | @MaximilianPress I was talking about more basic difference about p-value and power, objecting the claim that the rest of the SNPs met the HWE. However I do agree with you that, given the large number of tests, even the five SNPs with $p<0.05$ are not a proof that HWE is violated. | |
| Jan 5, 2021 at 21:12 | history | edited | Maximilian Press |
added statistics tag
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| Jan 5, 2021 at 21:12 | comment | added | Maximilian Press | I would quibble with @Vadim a bit- when you do 150 tests, you expect that $0.05 * 150 = 7.5$ SNPs to be $p < 0.05$, as under the null hypothesis, p-values from independent tests are uniformly distributed. P-values are a quite low standard of evidence except when they're very small. Having all 5 occur in one gene might be surprising, but nonetheless I would say that "rejecting" the null hypothesis based on it is a bit strong, as the observations are still pretty consistent with the null hypothesis (without seeing additional data). | |
| Jan 5, 2021 at 13:33 | comment | added | Roger V. | Be careful with the claims based on p-values: a p-value allows to reject the null hypothesis, but not to confitm it. In other words, when $p<0.05$ one can say that HWE is broken, however $p>0.05$ does not mean that HWE holds - it could be still broken, but we cannot prove it. | |
| Jan 5, 2021 at 13:15 | review | First posts | |||
| Jan 6, 2021 at 3:25 | |||||
| Jan 5, 2021 at 13:14 | history | asked | Fatma | CC BY-SA 4.0 |