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I read the following in a paper

It provides base-pair resolution and strand-specific information of **global RNA polymerase** occupancy. CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

What does this mean?

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  • $\begingroup$ Please provide a reference to the article/textbook you are citing. $\endgroup$
    – Domen
    Apr 21, 2022 at 13:43
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    $\begingroup$ "Global" tends to be used in contrast to "local". I think you need to read the paper to find out more specifically. $\endgroup$
    – David
    Apr 21, 2022 at 16:16
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    $\begingroup$ it looks like you are posting quotes without acknowledging them as as such or noting where they come from. It would help for you to clearly restate a more expansive version of your question outside of the title for us to be able to help more effectively. $\endgroup$
    – Maximilian Press
    Apr 21, 2022 at 18:22

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In context of the PRO-seq method, "global" can be substituted for "genome-wide". Note that use of the term global is a call-back to the methodological predecessor of PRO-seq, which was called global run-on sequencing (GRO-seq).

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