In the paper "A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle" by Martin et al. the authors try to disrupt the Ebola life-cycle by screening which human genes participate in it's replications:
In order to identify host factors involved in the EBOV life cycle, we performed a genome-wide siRNA screen comprising 64,755 individual siRNAs against 21,566 human genes to assess their activity in EBOV genome replication and transcription. As a screening platform, we used reverse genetics-based life cycle modelling systems that recapitulate these processes without the need for a BSL4 laboratory.
This helped them find a pathway.
What is siRNA screening and how does it help find a pathway?
[rna-interference] references siRNA:
A post-transcriptional mechanism of gene-regulation/silencing mediated by small RNAs (siRNA)
However, I can't tell if siRNA refers to "small RNAs" or the whole process.