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I'm studying bivalent promoters and enhancers. I understand that the same region of genome can have both H3K4me3 and H3K27me3. But can they occur on the same histone tail? Please provide me with a reference to support your answer.

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This paper suggests that people have tested if two proteins can bind on a histone tail that contains both epigenetic marks. This implies that indeed both markings can be on the same tail.

"Next, we investigated if a histone tail bearing both H3K4me3 and H3K27me3 marks can be combinatorially recognized by SHL."

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