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I am currently reading this research paper: https://www.nature.com/articles/1395848, and I'm confused by this line: "Serotonin Receptor mRNA Levels Are Unchanged by Acute LSD".

What is the exact meaning of this sentence? I could probably understand it as "immediate", that it doesn't pertain to long-term effect instead of short-term.

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In the abstract they refer to "acute LSD administration" (emphasis mine), and in the next section of the results after the one you mention in your question, they clarify it as "Acute LSD administration (1.0 mg/kg, 90 min)".

(That seems like an awful lot to me, as I understand typical recreational doses for humans are in the tens to hundreds of micrograms range.)

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  • $\begingroup$ Thanks for the answer! Just realized it now. 1.0 mg by itself is a lot, not even talking about 1.0 mg/kg. $\endgroup$
    – Timotej Leginus
    Jan 9, 2022 at 0:42
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    $\begingroup$ @TimotejLeginus Though these are rats so 1 mg/kg is probably about a 0.2-0.3 mg dose (the paper probably gives specific mass ranges for their animals but I'm just going by my memory of common sizes). Still a lot. $\endgroup$
    – Bryan Krause ♦
    Jan 9, 2022 at 2:21
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    $\begingroup$ @TimotejLeginus Just a small addition: the term acute generally means that a phenomenon/effect lasts for a short time period, in contrast to chronic which refers to a phenomenon that continues over a long period. This doesn't mean long term responses. There can be long term effects of an acute phenomenon. $\endgroup$
    – WYSIWYG
    Jan 10, 2022 at 10:15
  • $\begingroup$ thanks for the explanation! well I wasn't so sure about that, haven't found it anywhere, so I had to ask :) $\endgroup$
    – Timotej Leginus
    Jan 10, 2022 at 20:29

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